Abstract | BACKGROUND: SUMMARY: A 56-year-old woman with multiple endocrine neoplasia 2B syndrome, post subtotal thyroidectomy for MTC in childhood, presented with extensive metastatic spread of MTC to the lungs and liver, 47 years after the original diagnosis. The patient's calcitonin level decreased from 2950 to 261 pg/mL (reference range: <20 pg/mL) over a 20-year period. The serum CEA level was elevated at 6800 ng/mL (reference range: <5.1 ng/mL). Because of a concern for an alternate malignancy, serum CA 19-9 and CA 125 tumor markers were measured and found to be significantly elevated, at 39,334 U/mL (reference range: <35.1 U/mL) and 96.2 U/mL (reference range: 7-41 U/mL), respectively. Immunostaining of the metastatic MTC tissue showed patchy staining for calcitonin, strongly positive staining for CEA and CA 19-9, and weakly positive staining for CA 125. CONCLUSION: Drawing from experience with CA 19-9 and CA 125 tumor markers in other malignancies, we propose that they may be associated with aggressive forms of MTC with significant metastatic potential.
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Authors | Sofiya Milman, Kathleen D Whitney, Norman Fleischer |
Journal | Thyroid : official journal of the American Thyroid Association
(Thyroid)
Vol. 21
Issue 8
Pg. 913-6
(Aug 2011)
ISSN: 1557-9077 [Electronic] United States |
PMID | 21751886
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CA-125 Antigen
- CA-19-9 Antigen
- Codon
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Topics |
- Biomarkers, Tumor
(metabolism)
- CA-125 Antigen
(biosynthesis)
- CA-19-9 Antigen
(biosynthesis)
- Carcinoma, Neuroendocrine
- Codon
- Female
- Humans
- Middle Aged
- Multiple Endocrine Neoplasia Type 2b
(blood, complications)
- Mutation
- Neoplasm Metastasis
- Thyroid Neoplasms
(blood, complications, pathology)
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