Comparison of the sensitivity of C57BL/6J and AKR/J mice to airborne molecules of isovaleric acid and amyl acetate.

Abstract

Wysocki et al. (1977) have previously compared the abilities of several inbred strains of mice to avoid odorized drinks after odor-aversion conditioning and have proposed C57BL/6 mice as an animal model to study the specific anosmia to isovaleric acid. We have compared the olfactory performances of C57BL/6J mice and AKR/J mice using one-bottle and two-bottle tests to study the latencies of contacts with odorized or control drinks after odor-aversion conditioning. In both inbred strains, sensitivities to airborne molecules of amyl acetate (control odor) or isovaleric acid are demonstrated. Differences in behavioral strategies are suggested but the results are consistent with the hypothesis of a selective hyposmia to isovaleric acid in C57BL/6J mice.

• Authors: L Pourtier, G Sicard
• Journal: Behavior genetics (Behav Genet) Vol. 20 Issue 4 Pg. 499-509 (Jul 1990) ISSN: 0001-8244 [Print] United States
• PMID: 2175173 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Chlorides
• Hemiterpenes
• Pentanoic Acids
• Pentanols
• isovaleric acid
• amyl acetate
• Lithium
• Lithium Chloride

Topics

• Animals
• Association Learning (drug effects)
• Avoidance Learning (drug effects)
• Chlorides (pharmacology)
• Conditioning, Classical (drug effects)
• Hemiterpenes
• Lithium (pharmacology)
• Lithium Chloride
• Male
• Mice
• Mice, Inbred AKR
• Mice, Inbred C57BL
• Pentanoic Acids (pharmacology)
• Pentanols (pharmacology)
• Smell (genetics)
• Species Specificity