Radically resected epithelioid angiosarcoma that originated in the mediastinum.

Abstract

Angiosarcoma is a rare neoplasm, accounting for only 1%-2% of all sarcomas. It occurs most frequently in the skin and soft tissue and rarely in the thoracic region. To our knowledge, a mediastinal angiosarcoma is extremely rare. We report on the surgical resection of a rare case of giant epithelioid angiosarcoma originating in the anterior mediastinum, followed by six courses of adjuvant chemotherapy (doxorubicin + ifosfamide). The patient is alive and asymptomatic 1 year after surgery. As the prognosis for unresectable cases is generally dismal, surgical resection and adjuvant therapy can be an option for mediastinal angiosarcoma.

• Authors: Shinya Tane, Yugo Tanaka, Syunsuke Tauchi, Kazuya Uchino, Reiko Nakai, Masahiro Yoshimura
• Journal: General thoracic and cardiovascular surgery (Gen Thorac Cardiovasc Surg) Vol. 59 Issue 7 Pg. 503-6 (Jul 2011) ISSN: 1863-6713 [Electronic] Japan
• PMID: 21751114 (Publication Type: Case Reports, Journal Article)

Chemical References

• Doxorubicin
• Ifosfamide

Topics

• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Biopsy
• Chemotherapy, Adjuvant
• Doxorubicin (administration & dosage)
• Epithelioid Cells (pathology)
• Hemangiosarcoma (diagnosis, drug therapy, pathology, surgery)
• Humans
• Ifosfamide (administration & dosage)
• Immunohistochemistry
• Male
• Mediastinal Neoplasms (diagnosis, drug therapy, pathology, surgery)
• Neoplasm Invasiveness
• Positron-Emission Tomography
• Sternotomy
• Thoracic Surgical Procedures
• Tomography, X-Ray Computed
• Treatment Outcome
• Vascular Surgical Procedures