Abstract |
Owing to their low reactogenicity, confirmed efficacy and availability in combination vaccines, acellular pertussis (aP)-inactivated poliovirus (IPV) combined vaccines are now included in various national immunization programs worldwide. We provide an overview of 16 years of clinical experience with a diphtheria (D), tetanus (T), aP, IPV and Haemophilus influenzae type b (Hib) polysaccharide conjugated to tetanus protein (PRP∼T) combined vaccine (DTaP-IPV//PRP∼T - Pentaxim, Sanofi Pasteur, France). Good immunogenicity has been demonstrated after primary vaccination with Pentaxim, regardless of the population ethnicity and primary vaccination schedule. A booster vaccination in the second year of life also resulted in a high immune response for each antigen. Furthermore, 10 years of national surveillance in Sweden has demonstrated the effectiveness of Pentaxim in controlling pertussis. As is the case for other aP-containing combined vaccines, Pentaxim is well tolerated, with the safety profile being better than for whole-cell pertussis-containing combination vaccines for primary and booster vaccinations.
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Authors | Stanley A Plotkin, Johannes Liese, Shabir A Madhi, Esteban Ortiz |
Journal | Expert review of vaccines
(Expert Rev Vaccines)
Vol. 10
Issue 7
Pg. 981-1005
(Jul 2011)
ISSN: 1744-8395 [Electronic] England |
PMID | 21749196
(Publication Type: Journal Article, Review)
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Chemical References |
- Diphtheria-Tetanus-acellular Pertussis Vaccines
- Haemophilus Vaccines
- Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
- Tetanus Toxoid
- Vaccines, Combined
- Vaccines, Conjugate
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Topics |
- Child
- Child, Preschool
- Diphtheria-Tetanus-acellular Pertussis Vaccines
(administration & dosage, adverse effects, immunology, therapeutic use)
- Haemophilus Vaccines
(administration & dosage, adverse effects, immunology, therapeutic use)
- Humans
- Immunization Schedule
- Infant
- Infant, Newborn
- Sweden
- Tetanus Toxoid
(administration & dosage, adverse effects, immunology, therapeutic use)
- Vaccination
- Vaccines, Combined
(administration & dosage, adverse effects, immunology, therapeutic use)
- Vaccines, Conjugate
(administration & dosage, adverse effects, immunology, therapeutic use)
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