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A DTaP-IPV//PRP∼T vaccine (Pentaxim): a review of 16 years' clinical experience.

Abstract
Owing to their low reactogenicity, confirmed efficacy and availability in combination vaccines, acellular pertussis (aP)-inactivated poliovirus (IPV) combined vaccines are now included in various national immunization programs worldwide. We provide an overview of 16 years of clinical experience with a diphtheria (D), tetanus (T), aP, IPV and Haemophilus influenzae type b (Hib) polysaccharide conjugated to tetanus protein (PRP∼T) combined vaccine (DTaP-IPV//PRP∼T - Pentaxim, Sanofi Pasteur, France). Good immunogenicity has been demonstrated after primary vaccination with Pentaxim, regardless of the population ethnicity and primary vaccination schedule. A booster vaccination in the second year of life also resulted in a high immune response for each antigen. Furthermore, 10 years of national surveillance in Sweden has demonstrated the effectiveness of Pentaxim in controlling pertussis. As is the case for other aP-containing combined vaccines, Pentaxim is well tolerated, with the safety profile being better than for whole-cell pertussis-containing combination vaccines for primary and booster vaccinations.
AuthorsStanley A Plotkin, Johannes Liese, Shabir A Madhi, Esteban Ortiz
JournalExpert review of vaccines (Expert Rev Vaccines) Vol. 10 Issue 7 Pg. 981-1005 (Jul 2011) ISSN: 1744-8395 [Electronic] England
PMID21749196 (Publication Type: Journal Article, Review)
Chemical References
  • Diphtheria-Tetanus-acellular Pertussis Vaccines
  • Haemophilus Vaccines
  • Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
  • Tetanus Toxoid
  • Vaccines, Combined
  • Vaccines, Conjugate
Topics
  • Child
  • Child, Preschool
  • Diphtheria-Tetanus-acellular Pertussis Vaccines (administration & dosage, adverse effects, immunology, therapeutic use)
  • Haemophilus Vaccines (administration & dosage, adverse effects, immunology, therapeutic use)
  • Humans
  • Immunization Schedule
  • Infant
  • Infant, Newborn
  • Sweden
  • Tetanus Toxoid (administration & dosage, adverse effects, immunology, therapeutic use)
  • Vaccination
  • Vaccines, Combined (administration & dosage, adverse effects, immunology, therapeutic use)
  • Vaccines, Conjugate (administration & dosage, adverse effects, immunology, therapeutic use)

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