HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Zyflamend mediates therapeutic induction of autophagy to apoptosis in melanoma cells.

Abstract
Melanoma is the most aggressive form of skin cancer. The rising incidence of melanoma and its poor prognosis in advanced stages are compelling reasons to identify novel therapeutic agents. Though isolated dietary components such as lycopene, resveratrol, and isothiocyanate compounds have been shown to provide limited protection against cancer development, the use of whole herbs and herbal extracts for the treatment of cancer remains of great interest. As suggested by earlier studies, the antiinflammatory activity of many plants available as intact products or as extracts has long been considered for supplemental therapeutics for cancer. Zyflamend, a unique multiherbal extract preparation, is a promising antiinflammatory agent that has also been suggested to regulate multiple pathways in cancer progression. As Zyflamend contains ingredients that can suppress tumor cell proliferation, invasion, angiogenesis, and metastasis through regulation of inflammatory pathway products, we hypothesized that this preparation might inhibit melanoma proliferation. To test this hypothesis, we studied the effect of Zyflamend on melanoma proliferation. Here, we present that Zyflamend inhibits melanoma growth by regulating the autophagy-apoptosis switch. Based on the responsible molecular mechanisms of Zyflamend, our study highlights the importance of the use of herbal preparations for the prevention and treatment of cancer.
AuthorsSuhendan Ekmekcioglu, Chandrani Chattopadhyay, Ugur Akar, Abdul Gabisi Jr, Robert A Newman, Elizabeth A Grimm
JournalNutrition and cancer (Nutr Cancer) Vol. 63 Issue 6 Pg. 940-9 ( 2011) ISSN: 1532-7914 [Electronic] United States
PMID21745040 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References
  • Antineoplastic Agents
  • Plant Extracts
  • Zyflamend
Topics
  • Antineoplastic Agents (pharmacology)
  • Apoptosis (drug effects)
  • Autophagy (drug effects)
  • Blotting, Western
  • Cell Cycle (drug effects)
  • Cell Line, Tumor (drug effects)
  • Cell Proliferation (drug effects)
  • Cell Survival
  • Flow Cytometry
  • Humans
  • Immunohistochemistry
  • Melanoma (drug therapy, pathology)
  • Microscopy, Electron, Transmission
  • Phytotherapy
  • Plant Extracts (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: