Duloxetine in the treatment of binge eating disorder with depressive disorders: a placebo-controlled trial.

Abstract

OBJECTIVE:

This study evaluated duloxetine in the treatment of binge eating disorder (BED) with comorbid current depressive disorders.

METHOD:

In this 12-week, double-blind, placebo-controlled trial, 40 patients with Diagnostic and Statistical Manual of Mental Disorders-IV-TR BED and a comorbid current depressive disorder received duloxetine (N = 20) or placebo (N = 20). The primary outcome measure was weekly binge eating day frequency.

RESULTS:

In the primary analysis, duloxetine (mean 78.7 mg/day) was superior to placebo in reducing weekly frequency of binge eating days (p = .04), binge eating episodes (p = .02), weight (p = .04), and Clinical Global Impression-Severity of Illness ratings for binge eating (p = .02) and depressive disorders (p = .01). Changes in body mass index and measures of eating pathology, depression, and anxiety did not differ between the two groups.

DISCUSSION:

Duloxetine may be effective for reducing binge eating, weight, and global severity of illness in BED with a comorbid current depressive disorder, but this finding needs confirmation in larger, placebo-controlled trials.

• Authors: Anna I Guerdjikova, Susan L McElroy, Erin L Winstanley, Eric B Nelson, Nicole Mori, Jessica McCoy, Paul E Keck Jr, James I Hudson
• Journal: The International journal of eating disorders (Int J Eat Disord) Vol. 45 Issue 2 Pg. 281-9 (Mar 2012) ISSN: 1098-108X [Electronic] United States
• PMID: 21744377 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Wiley Periodicals, Inc.

Chemical References

• Antidepressive Agents
• Thiophenes
• Duloxetine Hydrochloride

Topics

• Adolescent
• Adult
• Aged
• Antidepressive Agents (therapeutic use)
• Binge-Eating Disorder (complications, drug therapy)
• Depressive Disorder (complications, drug therapy)
• Double-Blind Method
• Duloxetine Hydrochloride
• Female
• Humans
• Male
• Middle Aged
• Thiophenes (therapeutic use)
• Treatment Outcome