Abstract | OBJECTIVE AND DESIGN: The peptide from C-terminal domain of MCP-1 ( Ingramon) has been shown to inhibit monocyte migration and possess anti-inflammatory activity in animal models of inflammation and post-angioplasty restenosis. Here, we investigate the effect of Ingramon treatment on blood levels of acute-phase reactants and chemokines in patients after coronary stenting and the mechanisms of Ingramon anti-inflammatory activity. SUBJECTS: Eighty-seven patients with ischemic heart disease (IHD) who faced the necessity of coronary angiography (CA) were enrolled. In 67 patients, one-stage coronary stenting was performed; 33 of them were treated with Ingramon in addition to standard therapy. Twenty patients underwent CA only. METHODS: RESULTS AND CONCLUSIONS:
Ingramon treatment was accompanied by less pronounced elevation of hsCRP and fibrinogen levels and decreased MCP-1 concentration in plasma in patients after coronary stenting. Ingramon had no effect on MCP-1 interaction with cell receptors or MCP-1 dimerization, but inhibited MCP-1 binding to heparin. The anti-inflammatory activity of the peptide may be mediated by an impaired chemokine interaction with glycosaminoglycans.
|
Authors | T I Arefieva, T L Krasnikova, A V Potekhina, N U Ruleva, P I Nikitin, T I Ksenevich, B G Gorshkov, M V Sidorova, Zh D Bespalova, N B Kukhtina, S I Provatorov, E A Noeva, E I Chazov |
Journal | Inflammation research : official journal of the European Histamine Research Society ... [et al.]
(Inflamm Res)
Vol. 60
Issue 10
Pg. 955-64
(Oct 2011)
ISSN: 1420-908X [Electronic] Switzerland |
PMID | 21744268
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Anti-Inflammatory Agents
- Chemokine CCL2
- Peptide Fragments
- ingramon
- Fibrinogen
- Heparin
- C-Reactive Protein
|
Topics |
- Acute-Phase Reaction
- Aged
- Angina Pectoris
(pathology)
- Angioplasty
- Anti-Inflammatory Agents
(pharmacology)
- C-Reactive Protein
(metabolism)
- Chemokine CCL2
(metabolism)
- Coronary Angiography
(methods)
- Coronary Restenosis
- Female
- Fibrinogen
(metabolism)
- Heparin
(metabolism)
- Humans
- Male
- Middle Aged
- Monocytes
(cytology)
- Myocardial Ischemia
(pathology)
- Peptide Fragments
(pharmacology)
- Protein Binding
- Protein Structure, Tertiary
- Stents
|