Basal cell carcinoma arising in association with a maxillary keratocyst in a patient with Gorlin-Goltz syndrome. Report of a case.

Abstract

INTRODUCTION:

Gorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome, is an autosomal dominant inherited disorder which is characterized by the presence of multiple basal cell carcinomas, maxillary keratocysts, and musculoskeletal anomalies.

CASE REPORT:

We present a case of a patient suffering from Gorlin-Goltz syndrome who developed an intraosseous basal cell carcinoma associated with a recurrent maxillary keratocyst. To our knowledge, this is the first case of malignant transformation of a keratocyst into a basal cell carcinoma described in the literature.

CONCLUSION:

This case highlights the importance of careful histologic examination of keratocysts excised in patients suffering from Gorlin-Goltz syndrome.

• Authors: Maria Nikolaou Lazaridou, Ioannis Dimitrakopoulos, Ioannis Tilaveridis, Christos Iliopoulos, Antigoni Heva
• Journal: Oral and maxillofacial surgery (Oral Maxillofac Surg) Vol. 16 Issue 1 Pg. 127-31 (Mar 2012) ISSN: 1865-1569 [Electronic] Germany
• PMID: 21744042 (Publication Type: Case Reports, Journal Article)

Topics

• Adult
• Basal Cell Nevus Syndrome (genetics, pathology)
• Carcinoma, Basal Cell (genetics, pathology)
• Cell Transformation, Neoplastic (genetics, pathology)
• Chromosome Aberrations
• Disease Progression
• Follow-Up Studies
• Genes, Dominant (genetics)
• Humans
• Male
• Maxilla (pathology, surgery)
• Maxillary Diseases (genetics, pathology)
• Maxillary Neoplasms (genetics, pathology)
• Mitosis (physiology)
• Odontogenic Cysts (genetics, pathology)
• Radiography, Panoramic
• Reoperation