Abstract | BACKGROUND AND AIMS: Bone density and quality alterations worsen the ability of osteoporotic bone to support prosthetic implants. The aim of our study was to evaluate potential differences in bone quality and bone turnover markers in aged individuals undergoing surgery for hip fragility fracture or hip osteoarthritis. METHODS: Eighteen subjects with hip fragility fractures (Hip Fracture Group), 35 subjects with osteoarthritis of the hip ( Hip Osteoarthritis Group) and 19 subjects with normal femoral bone mineral density (Control Group) were evaluated. Serum and urinary bone markers were assayed preoperatively in all surgical patients, and within 48 hours after fracture in the Hip Fracture, Osteoarthritis and Control groups. Histomorphometric analysis was performed on surgical samples. RESULTS: CONCLUSIONS: Our data show significant differences in bone turnover markers in patients undergoing hip prosthesis for fragility fractures, compared with patients operated for hip osteoarthritis.
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Authors | Giuseppina Resmini, Silvia Migliaccio, Luca Dalle Carbonare, Umberto Sala, Marina Brama, Rachele Fornari, Stefania Maggi, Paola Siviero, Nazzarena Malavolta, Giovanni Iolascon |
Journal | Aging clinical and experimental research
(Aging Clin Exp Res)
Vol. 23
Issue 2
Pg. 99-105
(Apr 2011)
ISSN: 1594-0667 [Print] Germany |
PMID | 21743289
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Collagen Type I
- Isoenzymes
- Parathyroid Hormone
- Peptides
- collagen type I trimeric cross-linked peptide
- Acid Phosphatase
- Tartrate-Resistant Acid Phosphatase
- Calcium
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Topics |
- Acid Phosphatase
(blood)
- Aged
- Aged, 80 and over
- Aging
(metabolism, pathology)
- Biomarkers
(blood, urine)
- Bone Density
- Bone Remodeling
- Calcium
(blood, urine)
- Case-Control Studies
- Collagen Type I
(blood)
- Female
- Hip Fractures
(metabolism, pathology, surgery)
- Hip Prosthesis
- Humans
- Isoenzymes
(blood)
- Male
- Middle Aged
- Osteoarthritis, Hip
(metabolism, pathology, surgery)
- Parathyroid Hormone
(blood)
- Peptides
(blood)
- Pilot Projects
- Tartrate-Resistant Acid Phosphatase
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