Primary melanocytic tumors of the central nervous system: a neuroradiological and clinicopathological study of five cases and brief review of literature.

Primary melanocytic tumors of the central nervous system (CNS) are uncommon lesions. These lesions arise from the melanocytes located within leptomeninges and include diffuse melanocytosis and meningeal melanomatosis (seen in neurocutaneous melanosis), melanocytoma, and malignant melanoma. To study, the clinical course, neuroradiological features, morphology and immunohistochemistry of primary melanocytic tumor of CNS. Demographic, clinical and surgico-pathologic findings of five patients with melanocytic tumors seen between 1996 and 2003 were studied. In this study, five cases of primary melanocytic tumors have been reported: four cases of malignant melanoma and one case of melanocytoma. Three of the 5 cases were intracranial and 2 were spinal. The mean age in the present study was 26 years. Presenting features varied according to the location. Primary melanocytic tumor of CNS are rare. Whenever possible, complete surgical excision is the best treatment.
AuthorsSushila Jaiswal, Mukul Vij, Arun Tungria, Awadhesh Kumar Jaiswal, Arun Kumar Srivastava, Sanjay Behari
JournalNeurology India (Neurol India) 2011 May-Jun Vol. 59 Issue 3 Pg. 413-9 ISSN: 0028-3886 [Print] India
PMID21743173 (Publication Type: Journal Article)
  • Adolescent
  • Adult
  • Brain (pathology)
  • Brain Neoplasms (pathology, radiography, surgery)
  • Central Nervous System Neoplasms (pathology, radiography, surgery)
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanoma (pathology, radiography, surgery)
  • Neurosurgical Procedures
  • Spinal Cord (pathology)
  • Spinal Cord Neoplasms (pathology, radiography, surgery)
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Young Adult

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