Abstract | BACKGROUND: Vascular-disrupting agents (VDAs) represent a new class of chemotherapeutic agent that targets the existing vasculature in solid tumors. Preclinical and early-phase trials have demonstrated the promising therapeutic benefits of VDAs but have also uncovered a distinctive toxicity profile highlighted by cardiovascular events. METHODS: RESULTS: CONCLUSIONS: Early-phase trials of VDAs have revealed a cardiovascular toxicity profile similar to that of their vascular-targeting counterparts, the angiogenesis inhibitors. As these agents are added to the mainstream chemotherapeutic arsenal, careful identification of baseline cardiovascular risk factors would seem to be a prudent strategy. Close collaboration with cardiology colleagues for early indicators of serious cardiac adverse events will likely minimize toxicity while optimizing the therapeutic potential of VDAs and ultimately enhancing patient outcomes.
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Authors | Ishwaria M Subbiah, Daniel J Lenihan, Apostolia M Tsimberidou |
Journal | The oncologist
(Oncologist)
Vol. 16
Issue 8
Pg. 1120-30
( 2011)
ISSN: 1549-490X [Electronic] England |
PMID | 21742963
(Publication Type: Journal Article)
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Chemical References |
- Angiogenesis Inhibitors
- Bibenzyls
- N-acetylcochinol-O-phosphate
- Organophosphorus Compounds
- Quinazolines
- Xanthones
- vadimezan
- Serine
- combretastatin
- AC 7700
- verubulin
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Topics |
- Angiogenesis Inhibitors
(adverse effects, therapeutic use)
- Bibenzyls
(adverse effects, therapeutic use)
- Cardiovascular System
(drug effects)
- Clinical Trials as Topic
- Humans
- Neoplasms
(blood supply, drug therapy, pathology)
- Neovascularization, Pathologic
(drug therapy)
- Organophosphorus Compounds
(adverse effects, therapeutic use)
- Quinazolines
(adverse effects, therapeutic use)
- Serine
(adverse effects, analogs & derivatives, therapeutic use)
- Xanthones
(adverse effects, therapeutic use)
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