Improved diagnostic and prognostic performance of a new high-sensitive troponin T assay in patients with acute coronary syndrome.

Abstract

BACKGROUND:

In the present study, we aimed to analyze the diagnostic and prognostic potential of a newly developed high-sensitive troponin T assay and compared these results with those of a contemporary troponin T assay in 2 distinct patient cohorts, one including patients with evident ACS and the other one including patients with general chest pain.

METHODS AND RESULTS:

For this study, we analyzed data from 2 independent patient cohorts, the Bad Nauheim ACS registry and the Prognosis in Acute Coronary Syndromes registry, with a total of 2,506 patients. On admission, clinical data have been recorded, and a single measurement of troponin T has been performed with a contemporary assay (TnT) and a new high-sensitive troponin T assay (hsTnT). Clinical follow-up has been obtained after 6 months. The diagnostic value of hsTnT was superior to TnT (area under the receiver operating characteristic curve 0.949 vs 0.929, P = .016). Specifically, in TnT-negative patients, hsTnT provided strong diagnostic information (area under the receiver operating characteristic curve of 0.81, P < .001). Furthermore, hsTnT provided independent prognostic power for mortality within 6 months in both cohorts, which was superior to that of the contemporary TnT assay.

CONCLUSION:

Troponin T measured with a newly developed hsTnT provides better diagnostic and prognostic information and, therefore, should be implemented as a standard test in clinical routine.

• Authors: Michael Weber, Oscar Bazzino, Jose Luis Navarro Estrada, Raul de Miguel, Simon Salzberg, Juan J Fuselli, Christoph Liebetrau, Mariella Woelken, Helge Moellmann, Holger Nef, Christian Hamm
• Journal: American heart journal (Am Heart J) Vol. 162 Issue 1 Pg. 81-8 (Jul 2011) ISSN: 1097-6744 [Electronic] United States
• PMID: 21742093 (Publication Type: Comparative Study, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Mosby, Inc. All rights reserved.

Chemical References

• Biomarkers
• Troponin T

Topics

• Acute Coronary Syndrome (blood, diagnosis)
• Aged
• Biomarkers (blood)
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Humans
• Immunoassay
• Male
• Middle Aged
• Prognosis
• ROC Curve
• Registries
• Retrospective Studies
• Severity of Illness Index
• Troponin T (blood)