Propolis and amnion reepithelialise second-degree burns in rats.

Abstract

Burns are serious consequences of trauma in terms of both imminent mortality and prolonged periods of morbidity. They are often accompanied by unsatisfactory cosmetic as well as functional and psychological outcomes. These complications emphasise the need for stronger efforts in achieving greater diversity and effectiveness in the treatment of skin burns. This study aimed to verify the effectiveness of gross and microscopic epidermal and dermal responses in the process of regenerative repair or healing of burns in rats that were treated either daily with 5% propolis ointment or by autologous amnion graft. Second-degree burns were inflicted in the neck region of female rats by contact with a hot metal (at 130 °C) for 5 s. Propolis treatment accelerated the process of tissue repair and led to decreased local inflammation, which indicates that treatment with propolis was successful in the initial period (7 days) and stimulated the production of collagen fibre (assessed by morphometry) in all the periods evaluated (14 and 21 days). Amnion treatment inhibited local inflammation (assessed macroscopically), stimulated local epithelial regeneration (assessed microscopically) and stimulated the production of collagen fibre (assessed by morphometry) in the days following burn. These treatments offer new therapeutic strategies for treating severe skin burns; these strategies may allow the minimisation of scar formation, a more rapid return of function and, ultimately, a better quality of life for burn patients.

• Authors: Alicia Greyce Turatti Pessolato, Daniele dos Santos Martins, Carlos Eduardo Ambrósio, Celina Almeida Furlanetto Mançanares, Ana Flávia de Carvalho
• Journal: Burns : journal of the International Society for Burn Injuries (Burns) Vol. 37 Issue 7 Pg. 1192-201 (Nov 2011) ISSN: 1879-1409 [Electronic] Netherlands
• PMID: 21741176 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Elsevier Ltd and ISBI. All rights reserved.

Chemical References

• Anti-Infective Agents
• Ointments
• Collagen
• Propolis

Topics

• Amnion (transplantation)
• Animals
• Anti-Infective Agents (therapeutic use)
• Burns (pathology, therapy)
• Cicatrix, Hypertrophic (pathology)
• Collagen (analysis)
• Epithelium (pathology)
• Female
• Inflammation (pathology)
• Ointments
• Propolis (therapeutic use)
• Rats
• Transplantation, Autologous
• Wound Healing (drug effects)