Hemodynamic parameters obtained by transthoracic echocardiography and right heart catheterization: a comparative study in patients with pulmonary hypertension.

Abstract

BACKGROUND:

Hemodynamic evaluation is crucial for the management of patients with pulmonary hypertention. Clinicians often prefer a rapid and non-invasive method. This study aimed to examine the feasibility of transthoracic echocardiography for the measurements of hemodynamic parameters in patients with pulmonary hypertension.

METHODS:

A prospective single-center study was conducted among 42 patients with pulmonary hypertension caused by different diseases. Transthoracic echocardiography and right-heart catheterization were performed within 24 hours. Pulmonary artery systolic, diastolic and mean pressure (PASP, PADP and PAMP), cardiac output (CO), and pulmonary capillary wedge pressure (PCWP) were measured by both methods. A linear correlation and a Bland-Altman analysis were performed to compare the two groups of hemodynamic parameters.

RESULTS:

A good correlation was found between invasive and non-invasive measurements for PASP (r = 0.96), PADP (r = 0.85), PAMP (r = 0.88), CO (r = 0.82), and PCWP (r = 0.81). Further agreement analysis done by the Bland-Altman method showed that bias and a 95% confidence interval for PASP, PADP, and CO were clinically acceptable while great discrepancies existed for PAMP and PCWP.

CONCLUSIONS:

The non-invasive measurements by PASP, PADP, and CO in patients with pulmonary hypertension correlate well with the invasive determinations. Transthoracic echocardiography (TTE) was inappropriate for estimating PCWP and PAMP.

• Authors: Zhuang Tian, Yong-Tai Liu, Quan Fang, Chao Ni, Tai-Bo Chen, Li-Gang Fang, Peng Gao, Xiu-Chun Jiang, Meng-Tao Li, Xiao-Feng Zeng
• Journal: Chinese medical journal (Chin Med J (Engl)) Vol. 124 Issue 12 Pg. 1796-801 (Jun 2011) ISSN: 2542-5641 [Electronic] China
• PMID: 21740835 (Publication Type: Comparative Study, Journal Article)

Topics

• Adolescent
• Adult
• Cardiac Catheterization
• Cardiac Output
• Echocardiography
• Female
• Hemodynamics
• Humans
• Hypertension, Pulmonary (physiopathology)
• Male
• Middle Aged
• Prospective Studies
• Pulmonary Wedge Pressure