Abstract | CONTEXT: METHODS: A novel, highly sensitive method was developed for measuring all commercially available rodenticide-hydroxycoumarin anti- coagulants. Monthly brodifacoum levels were performed in two patients to determine half-life and expected time for levels to fall below 10 μg/L. RESULTS: We report two concurrent cases at our clinical toxicology service that required prolonged treatment with oral vitamin K to achieve normalisation of coagulation studies. Brodifacoum elimination appears to follow first-order kinetics. Case 1 had a brodifacoum elimination half-life of 33 days and was treated with vitamin K (100 mg) for 6 months. Case 2 was treated with vitamin K (100 mg) for 3 months with a half-life of 15 days. DISCUSSION:
|
Authors | Naren Gunja, Andrew Coggins, Sergei Bidny |
Journal | Clinical toxicology (Philadelphia, Pa.)
(Clin Toxicol (Phila))
Vol. 49
Issue 5
Pg. 385-90
(Jun 2011)
ISSN: 1556-9519 [Electronic] England |
PMID | 21740137
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- 4-Hydroxycoumarins
- Rodenticides
- Vitamin K
- bromfenacoum
|
Topics |
- 4-Hydroxycoumarins
(blood, poisoning)
- Adult
- Female
- Humans
- Male
- Middle Aged
- Rodenticides
(poisoning)
- Suicide
- Vitamin K
(therapeutic use)
|