Abstract | OBJECTIVE: MATERIAL AND METHODS: Eight girls and five boys, aged 7-19 years, who had urge incontinence refractory to scheduled voiding and anticholinergics, were included this prospective study. Urodynamic studies showed postoperative IDO in 12 patients. A dose of 50-100 IU (1.3 -- 4.8 IU/kg) BTX-A was primarily administered at 15-20 detrusor sites. A control urodynamic study was performed within 3 months after the injections. Seven patients had a repeated procedure 16 (range 6-24) months on the average after the first one. RESULTS: Eleven of the 13 patients had daily incontinence and two had incontinence a couple of times a week in association with urge symptoms. Postoperatively, no patient had urinary retention, but one girl had a urinary tract infection 4 months after the therapy. Five patients had a full response, seven partial responses and one no response 1-3 months after the first treatment. After 1 year, three of nine patients still have full response. Maximum cystometric capacity increased after the first treatment from a median of 227 ml to 379 ml (p = 0.005) and the number of patients with uninhibited detrusor contractions more than 30 cmH₂O during the filling phase decreased from eight to two out of 13 (p = 0.041). CONCLUSIONS: Intradetrusor BTX-A injections effectively reduce day-time wetting, significantly increase bladder volume and decrease detrusor overactivity in children with urge incontinence refractory to scheduled voidings and anticholinergics.
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Authors | T T Lahdes-Vasama, A Anttila, E Wahl, S Taskinen |
Journal | Scandinavian journal of urology and nephrology
(Scand J Urol Nephrol)
Vol. 45
Issue 6
Pg. 397-400
(Dec 2011)
ISSN: 1651-2065 [Electronic] England |
PMID | 21740110
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuromuscular Agents
- Botulinum Toxins, Type A
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Topics |
- Adolescent
- Adult
- Botulinum Toxins, Type A
(administration & dosage, therapeutic use)
- Child
- Female
- Humans
- Injections, Intramuscular
- Male
- Neuromuscular Agents
(administration & dosage, therapeutic use)
- Pilot Projects
- Prospective Studies
- Treatment Outcome
- Urinary Bladder, Overactive
(drug therapy)
- Urinary Incontinence, Urge
(drug therapy)
- Urodynamics
(drug effects)
- Young Adult
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