The central role of CD30L/CD30 interactions in allergic rhinitis pathogenesis in mice.

Abstract

CD30 ligand (CD30L) plays an important role in the amplification and/or activation of effector CD4(+) T cells, irrespective of Th cell subset. To examine the role of CD30L in allergic rhinitis, we evaluated an OVA model of allergic rhinitis in CD30L knock out (KO) mice on a BALB/c background sensitized with OVA. Symptoms of allergic rhinitis such as eosinophil infiltration into the nasal mucosa were drastically diminished in OVA-sensitized CD30L KO mice following intranasal challenge with OVA. The levels of OVA-specific IgE in the sera and the Th2 response in nasopharynx-associated lymphoid tissues and cervical LNs of CD30L KO mice were significantly lower than those of WT mice following intranasal challenge with OVA. Intranasal administration of CD30-Ig during the effector phase with OVA significantly prevented the development of allergic rhinitis in WT mice. These results suggest that CD30L plays an important role in allergic rhinitis and that the inhibition of CD30L/CD30 signaling might be useful as a novel biological therapy for allergic rhinitis.

• Authors: Takafumi Fuchiwaki, Xun Sun, Kenjiro Fujimura, Hisakata Yamada, Kensuke Shibata, Hiromi Muta, Eckhard R Podack, Hideyuki Kawauchi, Yasunobu Yoshikai
• Journal: European journal of immunology (Eur J Immunol) Vol. 41 Issue 10 Pg. 2947-54 (Oct 2011) ISSN: 1521-4141 [Electronic] Germany
• PMID: 21739429 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• CD30 Ligand
• Immunoglobulin G
• Ki-1 Antigen
• Recombinant Fusion Proteins
• Tnfsf8 protein, mouse
• Immunoglobulin E
• Ovalbumin

Topics

• Administration, Intranasal
• Animals
• CD30 Ligand (genetics, metabolism)
• CD4-Positive T-Lymphocytes (immunology, metabolism)
• Cell Movement
• Eosinophils (immunology, metabolism)
• Immunoglobulin E (blood)
• Immunoglobulin G (pharmacology)
• Ki-1 Antigen (metabolism)
• Lymph Nodes (immunology)
• Mice
• Mice, Inbred BALB C
• Mice, Knockout
• Nasal Mucosa (immunology)
• Nasopharynx (immunology)
• Ovalbumin (immunology)
• Recombinant Fusion Proteins (pharmacology)
• Rhinitis, Allergic, Perennial (immunology)
• Th2 Cells (immunology)