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Response to rituximab in 3 children with opsoclonus-myoclonus syndrome resistant to conventional treatments.

Abstract
We report the 1 year follow-up of 3 children affected by non-paraneoplastic Opsoclonus-Myoclonus Syndrome (OMS) resistant to conventional therapies (steroids, ACTH and intravenous immunoglobulins) who were treated with an anti CD20 monoclonal antibody (rituximab). Treatment response was recorded on the basis of an international score at 0, 3, 6, 9 and 12 months. Despite the long disease duration and the numerous previously administered treatments, all patients underwent rapid and persistent neurological recovery following rituximab administration, thus suggesting a potential role of this drug even in pre-treated patients.
AuthorsTeresa Battaglia, Elisa De Grandis, Marisol Mirabelli-Badenier, Luca Boeri, Guido Morcaldi, Paola Barabino, Chiara Intra, Francesca Naselli, Vito Pistoia, Edvige Veneselli, Massimo Conte
JournalEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society (Eur J Paediatr Neurol) Vol. 16 Issue 2 Pg. 192-5 (Mar 2012) ISSN: 1532-2130 [Electronic] England
PMID21737325 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal, Murine-Derived
  • Immunoglobulins, Intravenous
  • Rituximab
  • Dexamethasone
  • Adrenocorticotropic Hormone
  • Prednisone
Topics
  • Adrenocorticotropic Hormone (therapeutic use)
  • Anti-Inflammatory Agents (therapeutic use)
  • Antibodies, Monoclonal, Murine-Derived (therapeutic use)
  • Ataxia (drug therapy, etiology)
  • Child Behavior Disorders (etiology, psychology)
  • Dexamethasone (therapeutic use)
  • Drug Resistance
  • Electroencephalography
  • Gait Disorders, Neurologic (drug therapy, etiology)
  • Humans
  • Immunoglobulins, Intravenous (therapeutic use)
  • Infant
  • Magnetic Resonance Imaging
  • Male
  • Opsoclonus-Myoclonus Syndrome (drug therapy)
  • Prednisone (therapeutic use)
  • Rituximab
  • Speech Disorders (drug therapy, etiology)
  • Treatment Outcome
  • Tremor (drug therapy, etiology)
  • Virus Diseases (complications)

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