Abstract |
We report the 1 year follow-up of 3 children affected by non-paraneoplastic Opsoclonus-Myoclonus Syndrome (OMS) resistant to conventional therapies ( steroids, ACTH and intravenous immunoglobulins) who were treated with an anti CD20 monoclonal antibody ( rituximab). Treatment response was recorded on the basis of an international score at 0, 3, 6, 9 and 12 months. Despite the long disease duration and the numerous previously administered treatments, all patients underwent rapid and persistent neurological recovery following rituximab administration, thus suggesting a potential role of this drug even in pre-treated patients.
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Authors | Teresa Battaglia, Elisa De Grandis, Marisol Mirabelli-Badenier, Luca Boeri, Guido Morcaldi, Paola Barabino, Chiara Intra, Francesca Naselli, Vito Pistoia, Edvige Veneselli, Massimo Conte |
Journal | European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
(Eur J Paediatr Neurol)
Vol. 16
Issue 2
Pg. 192-5
(Mar 2012)
ISSN: 1532-2130 [Electronic] England |
PMID | 21737325
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2011 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. |
Chemical References |
- Anti-Inflammatory Agents
- Antibodies, Monoclonal, Murine-Derived
- Immunoglobulins, Intravenous
- Rituximab
- Dexamethasone
- Adrenocorticotropic Hormone
- Prednisone
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Topics |
- Adrenocorticotropic Hormone
(therapeutic use)
- Anti-Inflammatory Agents
(therapeutic use)
- Antibodies, Monoclonal, Murine-Derived
(therapeutic use)
- Ataxia
(drug therapy, etiology)
- Child Behavior Disorders
(etiology, psychology)
- Dexamethasone
(therapeutic use)
- Drug Resistance
- Electroencephalography
- Gait Disorders, Neurologic
(drug therapy, etiology)
- Humans
- Immunoglobulins, Intravenous
(therapeutic use)
- Infant
- Magnetic Resonance Imaging
- Male
- Opsoclonus-Myoclonus Syndrome
(drug therapy)
- Prednisone
(therapeutic use)
- Rituximab
- Speech Disorders
(drug therapy, etiology)
- Treatment Outcome
- Tremor
(drug therapy, etiology)
- Virus Diseases
(complications)
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