[Antitumor effects of sulindac in ovarian cell cultures].

Abstract

OBJECTIVE:

The purpose of our study was to assess susceptibility of cells of various ovarian cell lines on different nonsteroidal anti-inflammatory drugs (NSAIDs).

MATERIALS AND METHODS:

Cytotoxic effect of NSAIDs was tested using MTT colorimetric assay.

RESULTS:

Amongst 6 NSAIDs tested: sulindac, sulindac sulfide, sulindac sulfone, acetylsalicylic acid, nimesulide, and rofecoxib, viability of ovarian carcinoma cells was compromised most strongly by sulindac and sulindac sulfide and concerned all the cell lines tested: SKOV-3, MDAH 2774, OVCA-1, and OVP-10. Sulindac sulfone and rofecoxib also displayed some cytotoxic effect during prolonged 72-hour incubation. Other NSAIDs tested: nimesulide and acetylsalicylic acid were devoid of cytotoxic effect on ovarian cancer cells.

CONCLUSION:

Our results are encourage enough to conduct clinical trials that could allow to draw conclusions regarding potential application of sulindac in the adjuvant treatment of a standard chemotherapy of ovarian cancer.

• Authors: Anna Jakubowska-Mućka, Jacek Sieńko, Tomasz Switaj, Jakub Gołab, Witold Lasek
• Journal: Ginekologia polska (Ginekol Pol) Vol. 82 Issue 3 Pg. 195-9 (Mar 2011) ISSN: 0017-0011 [Print] Poland
• Vernacular Title: Przeciwnowotworowy efekt sulindaku w hodowlach komórek raka jajnika.
• PMID: 21735687 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antineoplastic Agents
• Lactones
• Sulfonamides
• Sulfones
• rofecoxib
• Sulindac
• sulindac sulfide
• sulindac sulfone
• Aspirin
• nimesulide

Topics

• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Antineoplastic Agents (pharmacology)
• Aspirin (pharmacology)
• Cell Cycle (drug effects)
• Cell Size (drug effects)
• Cell Survival (drug effects)
• Colorimetry
• Female
• Humans
• Lactones (pharmacology)
• Ovarian Neoplasms (drug therapy)
• Sulfonamides (pharmacology)
• Sulfones (pharmacology)
• Sulindac (analogs & derivatives, pharmacology)
• Tumor Cells, Cultured (drug effects)