Abstract | PURPOSE: METHODS: This prospective clinical study to evaluate the role of technetium ((99m)Tc)-ciprofloxacin scan as a tool to assess disease activity involved in 15 cases of TB spine with a mean age of 32.2 years (range 21-72). Following a clinico-radiological diagnosis, all patients were treated with standard anti tubercular treatment and a scan was done at zero, three and six months of treatment with tracer activity being recorded and compared in sequential scans along with a parallel evaluation of clinical and radiological profile at regular intervals. RESULTS: Out of 15 cases, nine had an initially positive bone scan. Two patients (22%) converted to negative scans at three months, whereas the remaining seven (78%) turned negative at six months. The end of six months treatment was also accompanied by clinico-radiological resolution in all cases. CONCLUSION: In conclusion, technetium ((99m)Tc)-ciprofloxacin scan could be a promising tool for monitoring disease activity in selected cases of tuberculosis spine as an alternative for therapeutic drug monitoring; however, due to the small sample size, studies with a large number of patients might be of help in defining these cases in a better way.
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Authors | Mayank Agrawal, Vikas Bhardwaj, Wangchuk Tsering, Sumit Sural, Ravi Kashyap, Anil Dhal |
Journal | International orthopaedics
(Int Orthop)
Vol. 36
Issue 2
Pg. 271-6
(Feb 2012)
ISSN: 1432-5195 [Electronic] Germany |
PMID | 21735206
(Publication Type: Journal Article)
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Chemical References |
- 99mTc-CPFXDTC
- Organotechnetium Compounds
- Thiocarbamates
- Ciprofloxacin
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Topics |
- Adult
- Aged
- Ciprofloxacin
(analogs & derivatives)
- Comorbidity
- Diabetes Mellitus
(epidemiology)
- Female
- Humans
- Magnetic Resonance Imaging
- Male
- Middle Aged
- Organotechnetium Compounds
- Prospective Studies
- Radionuclide Imaging
- Thiocarbamates
- Tuberculosis, Spinal
(diagnosis, diagnostic imaging, epidemiology)
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