Abstract |
The influence of repeated treatment with desipramine or AR-C239 on cerebral cortex alpha 1-adrenoceptors of mature (4 months), senescent (24 months) Wistar-Kyoto and mature spontaneously hypertensive rats was measured using [3H] prazosin as a ligand. Chronic desipramine treatment had no effect on [3H] prazosin binding in mature and aged Wistar-Kyoto rats but significantly decreased it in spontaneously hypertensive rats. Repeated AR-C239 treatment did not alter [3H] prazosin binding in senescent Wistar-Kyoto and mature spontaneously hypertensive rats, but significantly increased the [3H] prazosin binding density in mature Wistar-Kyoto rats. Thus, cortical alpha 1-adrenoceptors are not up-regulated by a decreased noradrenergic activity in aged or hypertensive rats as is the case in mature normotensive rats. In addition, these receptors are down-regulated by an increased noradrenergic activity in hypertensive rats only. These results suggest that the synthesis of alpha 1-adrenoceptors is impaired with age or with genetic hypertension and their degeneration is exacerbated with genetic hypertension in response to a changing environment.
|
Authors | F Huguet |
Journal | Archives internationales de pharmacodynamie et de therapie
(Arch Int Pharmacodyn Ther)
1990 May-Jun
Vol. 305
Pg. 5-13
ISSN: 0003-9780 [Print] Belgium |
PMID | 2173510
(Publication Type: Journal Article)
|
Chemical References |
- Isoquinolines
- Piperazines
- Receptors, Adrenergic, alpha
- AR-C239
- Desipramine
- Prazosin
|
Topics |
- Aging
(metabolism)
- Animals
- Brain Chemistry
(drug effects)
- Desipramine
(pharmacology)
- Hypertension
(metabolism)
- Isoquinolines
(pharmacology)
- Male
- Piperazines
- Prazosin
(metabolism)
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY
- Receptors, Adrenergic, alpha
(metabolism)
|