Liposomal amphotericin B-induced hypotension leading to ST segment elevated myocardial infarction.

Abstract

We hereby report a short case of 71-year-old gentleman who developed ST segment elevation myocardial infarction shortly after starting the infusion of liposomal amphotericin B for disseminated histoplasmosis. We also discuss the novel pathogenesis of specific liposomal component of amphotericin B that contributed to the acute cardiopulmonary compromise in our patient leading to subsequent myocardial infarction.

• Authors: Harsh Golwala, Nishit Patel, Soni Zacharias, Pedro Lozano
• Journal: American journal of therapeutics (Am J Ther) Vol. 18 Issue 5 Pg. e157-8 (Sep 2011) ISSN: 1536-3686 [Electronic] United States
• PMID: 21734533 (Publication Type: Case Reports, Journal Article)
• Copyright: (C) 2011 Lippincott Williams & Wilkins, Inc.

Chemical References

• Antifungal Agents
• liposomal amphotericin B
• Amphotericin B

Topics

• Aged
• Amphotericin B (adverse effects, therapeutic use)
• Antifungal Agents (adverse effects, therapeutic use)
• Histoplasmosis (drug therapy)
• Humans
• Hypotension (chemically induced)
• Male
• Myocardial Infarction (chemically induced)