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[No complaints, but constantly elevated cholestatic serum liver tests].

Abstract
A 75 year old woman presented with long-lasting pruritus and elevation of serum levels of alkaline phosphatase and gamma-glutamyl transpeptidase (GGT). Potentially hepatotoxic drugs were stopped; an abdominal ultra-sonography was normal. Antimitochondrial antibodies were elevated and are the serologic hallmark of primary biliary cirrhosis. The disease can progress from an asymptomatic inflammation to a cirrhosis. The disease-modifying treatment consists in ursodeoxycholic acid 13-15 mg/kg per day. Concomitant to the primary biliary cirrhosis hypothyroidism, osteoporosis, malabsorption and dyslipidemia can occur.
AuthorsH Kherbèche
JournalPraxis (Praxis (Bern 1994)) Vol. 100 Issue 14 Pg. 865-7 (Jul 06 2011) ISSN: 1661-8157 [Print] Switzerland
Vernacular Title(Fast) beschwerdefreie Patientin, aber konstant erhöhte Cholestaseparameter.
PMID21732301 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Autoantibodies
  • Ursodeoxycholic Acid
  • gamma-Glutamyltransferase
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • Alkaline Phosphatase
Topics
  • Aged
  • Alanine Transaminase (blood)
  • Alkaline Phosphatase (blood)
  • Aspartate Aminotransferases (blood)
  • Autoantibodies (blood)
  • Cholangitis, Sclerosing (diagnosis, drug therapy, enzymology)
  • Cholestasis (drug therapy, enzymology, etiology)
  • Diagnosis, Differential
  • Female
  • Humans
  • Liver Cirrhosis, Biliary (diagnosis, drug therapy, enzymology)
  • Liver Function Tests
  • Mitochondria, Liver (immunology)
  • Ultrasonography
  • Ursodeoxycholic Acid (therapeutic use)
  • gamma-Glutamyltransferase (blood)

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