Abstract | BACKGROUND:
C-reactive protein [CRP] levels increase to hundreds of mg/mL within hours following infection. Studies have shown that serum CRP levels were elevated in periodontal disease. However, in all the previous studies, CRP levels were measured by using high-sensitivity CRP assay kits with minimal detection limits of 0.1 to 3 mg/L, which was much below the normal value of 10 mg/L. These high-sensitivity CRP assays need a proper laboratory setup, and these methods cannot be used as a routine chair-side test in the dental office. AIM: The purpose of this study was to investigate the serum CRP levels in subjects with periodontal disease by using a rapid chair-side diagnostic test kit with a lower detection limit of 6 mg/L and to compare the CRP levels before and after periodontal therapy. MATERIALS AND METHODS: A total of 45 systemically healthy subjects were selected for the study. Subjects were divided into three groups: group A: healthy controls, group B: gingivitis, group C: periodontitis. Serum levels of CRP were determined by using a latex slide agglutination method with commercially available kit with lower detection limit of 6 mg/L. RESULTS: CRP was negative in all the 15 subjects in groups A and B at baseline, 7th and 30th day. CRP was positive only in 2 subjects in Group C at baseline and 7th day. CONCLUSION:
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Authors | Girish Nagarale, S Ravindra, Srinath Thakur, Swati Setty |
Journal | Journal of Indian Society of Periodontology
(J Indian Soc Periodontol)
Vol. 14
Issue 4
Pg. 213-6
(Oct 2010)
ISSN: 0975-1580 [Electronic] India |
PMID | 21731244
(Publication Type: Journal Article)
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