Meningitis caused by Filobasidium uniguttulatum: case report and overview of the literature.

Cryptococcal meningitis is mainly caused by Cryptococcus neoformans and Cryptococcus gattii, but occasionally other Cryptococcus species and phylogenetically related species are involved. Herein, we present a case of cryptococcal meningitis from China, which was caused by an azole and flucytosine resistant Filobasidium uniguttulatum. In addition, we present an overview of the literature of meningitis caused by Cryptococcus species other than C. neoformans and C. gattii. Eight cases were related to infections of the central nervous system. Leukaemia and cancer were important risk factors in HIV-negative patients. Molecular identification and susceptibility testing are important for proper management of patients because the species involved may differ in susceptibility to antifungal drugs.
AuthorsWeihua Pan, Wanqing Liao, Ferry Hagen, Bart Theelen, Weimin Shi, Jacques F Meis, Teun Boekhout
JournalMycoses (Mycoses) Vol. 55 Issue 2 Pg. 105-9 (Mar 2012) ISSN: 1439-0507 [Electronic] Germany
PMID21729175 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
Copyright© 2011 Blackwell Verlag GmbH.
Chemical References
  • Antifungal Agents
  • Amphotericin B
  • Flucytosine
  • Adult
  • Aged
  • Amphotericin B (administration & dosage, therapeutic use)
  • Antifungal Agents (administration & dosage, therapeutic use)
  • Basidiomycota
  • Drug Resistance, Fungal
  • Female
  • Flucytosine (administration & dosage, therapeutic use)
  • Humans
  • Male
  • Meningitis, Cryptococcal (diagnosis, drug therapy, microbiology)
  • Microbial Sensitivity Tests
  • Mycological Typing Techniques

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