Deregulated expression of superoxide dismutase-2 correlates with different stages of cervical neoplasia.

Abstract

OBJECTIVE:

Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.

METHODS:

In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).

RESULTS:

We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.

CONCLUSIONS:

Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.

• Authors: Lara Termini, Adhemar Longatto Filho, Paulo Cesar Maciag, Daniela Etlinger, Venâncio Avancini Ferreira Alves, Suely Nonogaki, Fernando Augusto Soares, Luisa Lina Villa
• Journal: Disease markers (Dis Markers) Vol. 30 Issue 6 Pg. 275-81 ( 2011) ISSN: 1875-8630 [Electronic] United States
• PMID: 21725155 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Superoxide Dismutase
• superoxide dismutase 2

Topics

• Adenocarcinoma (genetics, metabolism, pathology)
• Biomarkers, Tumor (genetics, metabolism)
• Carcinoma, Squamous Cell (genetics, metabolism, pathology)
• Female
• Gene Expression Regulation, Neoplastic
• Humans
• Neoplasm Staging
• Odds Ratio
• Superoxide Dismutase (genetics, metabolism)
• Uterine Cervical Neoplasms (genetics, metabolism, pathology)
• Uterine Cervical Dysplasia (genetics, metabolism, pathology)