Abstract |
We herein report a case of signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous ( colloid) adenocarcinoma. A 79-year-old female presented with a pulmonary tumor located in the right lower lobe measuring 21 mm in size. A right lower lobectomy was performed. The postoperative pathological examination revealed signet ring cell carcinoma with abundant mucin pools, and a multiplex RT-PCR analysis revealed the variant 2 inversion of the EML4-ALK gene.
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Authors | Taro Ohba, Kenji Sugio, Takuro Kometani, Masafumi Yamaguchi, Motoharu Hamatake, Kaname Nosaki, Hiroaki Takeoka, Hiromoto Kitajima, Fumihiko Hirai, Takashi Seto, Kenichi Taguchi, Kenichi Nishiyama, Yoshitaka Shida, Yukito Ichinose |
Journal | Lung cancer (Amsterdam, Netherlands)
(Lung Cancer)
Vol. 73
Issue 3
Pg. 375-8
(Sep 2011)
ISSN: 1872-8332 [Electronic] Ireland |
PMID | 21719143
(Publication Type: Case Reports, Journal Article)
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Copyright | Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Carcinoembryonic Antigen
- EML4-ALK fusion protein, human
- Oncogene Proteins, Fusion
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Topics |
- Adenocarcinoma, Mucinous
(diagnosis, genetics, pathology, physiopathology, surgery)
- Aged
- Carcinoembryonic Antigen
(blood)
- Carcinoma, Signet Ring Cell
(diagnosis, genetics, pathology, physiopathology, surgery)
- Chest Pain
- DNA Mutational Analysis
- Diagnosis, Differential
- Disease Progression
- Disease-Free Survival
- Female
- Humans
- Lung
(diagnostic imaging, metabolism, pathology)
- Lung Neoplasms
(diagnosis, genetics, pathology, physiopathology, surgery)
- Oncogene Proteins, Fusion
(genetics, metabolism)
- Pneumonectomy
- Radiography
- Radionuclide Imaging
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