Signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma: a case report.

Abstract

We herein report a case of signet ring cell adenocarcinoma of the lung with an EML4-ALK fusion gene mimicking mucinous (colloid) adenocarcinoma. A 79-year-old female presented with a pulmonary tumor located in the right lower lobe measuring 21 mm in size. A right lower lobectomy was performed. The postoperative pathological examination revealed signet ring cell carcinoma with abundant mucin pools, and a multiplex RT-PCR analysis revealed the variant 2 inversion of the EML4-ALK gene.

• Authors: Taro Ohba, Kenji Sugio, Takuro Kometani, Masafumi Yamaguchi, Motoharu Hamatake, Kaname Nosaki, Hiroaki Takeoka, Hiromoto Kitajima, Fumihiko Hirai, Takashi Seto, Kenichi Taguchi, Kenichi Nishiyama, Yoshitaka Shida, Yukito Ichinose
• Journal: Lung cancer (Amsterdam, Netherlands) (Lung Cancer) Vol. 73 Issue 3 Pg. 375-8 (Sep 2011) ISSN: 1872-8332 [Electronic] Ireland
• PMID: 21719143 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Chemical References

• Carcinoembryonic Antigen
• EML4-ALK fusion protein, human
• Oncogene Proteins, Fusion

Topics

• Adenocarcinoma, Mucinous (diagnosis, genetics, pathology, physiopathology, surgery)
• Aged
• Carcinoembryonic Antigen (blood)
• Carcinoma, Signet Ring Cell (diagnosis, genetics, pathology, physiopathology, surgery)
• Chest Pain
• DNA Mutational Analysis
• Diagnosis, Differential
• Disease Progression
• Disease-Free Survival
• Female
• Humans
• Lung (diagnostic imaging, metabolism, pathology)
• Lung Neoplasms (diagnosis, genetics, pathology, physiopathology, surgery)
• Oncogene Proteins, Fusion (genetics, metabolism)
• Pneumonectomy
• Radiography
• Radionuclide Imaging