Abstract |
This review will discuss the current state of the human HIV-1 vaccine trials including the safety consideration of vaccine composition and difficulties in determining and defining protective immunity and epitopes to HIV-1. Vaccines in animal models of lentivirus infection are compared. In particular, the findings from the prototype FIV vaccine and the HIV-1 protein immunizations studies in cats are discussed, as well as the resulting research regarding a potential HIV-1 vaccine design based on evolutionarily conserved T-cell epitopes.
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Authors | J R Abbott, M P Sanou, J K Coleman, J K Yamamoto |
Journal | Veterinary immunology and immunopathology
(Vet Immunol Immunopathol)
Vol. 143
Issue 3-4
Pg. 246-54
(Oct 15 2011)
ISSN: 1873-2534 [Electronic] Netherlands |
PMID | 21719117
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2011 Elsevier B.V. All rights reserved. |
Chemical References |
- AIDS Vaccines
- Epitopes, T-Lymphocyte
- Vaccines, Synthetic
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Topics |
- AIDS Vaccines
(genetics, immunology)
- Animals
- Cats
(virology)
- Clinical Trials as Topic
- Conserved Sequence
(genetics)
- Epitope Mapping
- Epitopes, T-Lymphocyte
(genetics)
- HIV Infections
(immunology)
- HIV-1
(immunology)
- Humans
- Immunodeficiency Virus, Feline
(genetics, immunology)
- Vaccines, Synthetic
(genetics, immunology)
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