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Evolutionarily conserved T-cell epitopes on FIV for designing an HIV/AIDS vaccine.

Abstract
This review will discuss the current state of the human HIV-1 vaccine trials including the safety consideration of vaccine composition and difficulties in determining and defining protective immunity and epitopes to HIV-1. Vaccines in animal models of lentivirus infection are compared. In particular, the findings from the prototype FIV vaccine and the HIV-1 protein immunizations studies in cats are discussed, as well as the resulting research regarding a potential HIV-1 vaccine design based on evolutionarily conserved T-cell epitopes.
AuthorsJ R Abbott, M P Sanou, J K Coleman, J K Yamamoto
JournalVeterinary immunology and immunopathology (Vet Immunol Immunopathol) Vol. 143 Issue 3-4 Pg. 246-54 (Oct 15 2011) ISSN: 1873-2534 [Electronic] Netherlands
PMID21719117 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
CopyrightCopyright © 2011 Elsevier B.V. All rights reserved.
Chemical References
  • AIDS Vaccines
  • Epitopes, T-Lymphocyte
  • Vaccines, Synthetic
Topics
  • AIDS Vaccines (genetics, immunology)
  • Animals
  • Cats (virology)
  • Clinical Trials as Topic
  • Conserved Sequence (genetics)
  • Epitope Mapping
  • Epitopes, T-Lymphocyte (genetics)
  • HIV Infections (immunology)
  • HIV-1 (immunology)
  • Humans
  • Immunodeficiency Virus, Feline (genetics, immunology)
  • Vaccines, Synthetic (genetics, immunology)

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