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[Anti-obesity drugs: status quo and recent advances].

Abstract
Obesity has become a major health problem worldwide. The prevalence and morbidity of obesity-related diseases including diabetes, hypertension, cerebro-cardiovascular diseases, and tumors also have remarkably increased. Treatment of obesity poses a challenge for clinicians. Anti-obesity treatment is helpful to improve and even reverse obesity-related complications. Diet control and physical exercises remain the predominant interventions for obese patients. Anti-obesity drugs can be considered in those who respond poorly to behavioral intervention or those who have developed obesity-related complications. The commonly used anti-obesity drugs include gastrointestinal lipase inhibitors and appetite suppressants. Glucagon-like peptide 1 has also been found to be effective in reducing body weight. Some more drugs are under development, which include selective 5-HT 2c agonist, β3 receptor agonist, and melanocortin receptor 4 agonist, may also be promising.
AuthorsHui-juan Zhu, Zi-meng Jin
JournalZhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae (Zhongguo Yi Xue Ke Xue Yuan Xue Bao) Vol. 33 Issue 3 Pg. 243-7 (Jun 2011) ISSN: 1000-503X [Print] China
PMID21718603 (Publication Type: Journal Article)
Chemical References
  • Anti-Obesity Agents
  • Appetite Depressants
  • Glucagon-Like Peptide 1
Topics
  • Anti-Obesity Agents (therapeutic use)
  • Appetite Depressants (therapeutic use)
  • Glucagon-Like Peptide 1 (therapeutic use)
  • Humans
  • Obesity (drug therapy)

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