Photolon enhancement of ultrasound cytotoxicity.

Abstract

OBJECTIVE:

To evaluate the impact of Photolon on cytostatic and cytotoxic effects of therapeutic range ultrasound in C6 glioma cells.

METHODS:

C6 glioma cells in suspension or monolayer cell culture were exposed to ultrasound (880 kHz, 0.2-0.7 W/cm2) in the presence or absence of Photolon at the concentration of 1 μg/ml in the culture medium, and then cell viability was evaluated.

RESULTS:

Photolon increased the cytotoxic effect of ultrasound by 1.5-2.3-fold but had no effect on its cytostatic activity.

CONCLUSION:

Photolon produces a pronounced sonosensitizing effect on glioma C6 cells and is a promising drug for sonodynamic treatment of malignant tumors.

• Authors: D A Tserkovsky, E N Alexandrova, Yu P Istomin
• Journal: Experimental oncology (Exp Oncol) Vol. 33 Issue 2 Pg. 107-9 (Jun 2011) ISSN: 1812-9269 [Print] Ukraine
• PMID: 21716209 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents
• Chlorophyllides
• Porphyrins
• Protoporphyrins
• phytochlorin
• Povidone

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Brain Neoplasms (pathology, therapy)
• Cell Survival
• Chlorophyllides
• Glioma (pathology, therapy)
• Porphyrins
• Povidone (pharmacology)
• Protoporphyrins (pharmacology)
• Rats
• Tumor Cells, Cultured
• Ultrasonic Therapy