Feasibility of tomotherapy for Graves' ophthalmopathy: Dosimetry comparison with conventional radiotherapy.

Abstract

PURPOSE:

To compare the dosimetry of tomotherapy and the conventional half-beam technique (HBT) or non-split beam technique (NSBT) for target coverage and radiation dose to the lacrimal glands and lens.

PATIENTS AND METHODS:

A retrospective review of 7 patients with Graves' ophthalmopathy who had radiotherapy because of disease progression on high steroid dose is reported: 3 patients were treated with tomotherapy and 4 patients with HBT.

RESULTS:

Compared to HBT, tomotherapy may provide better target coverage and significant reduction of radiation dose to the lacrimal glands and a higher dose to the lens. The NSBT improved target coverage but resulted in significantly higher doses to the lens and lacrimal glands.

CONCLUSION:

Tomotherapy may provide better coverage of the target volume and may be more effective in reducing severe exophthalmos compared to the conventional radiotherapy technique.

• Authors: Nam P Nguyen, Shane P Krafft, Paul Vos, Vincent Vinh-Hung, Misty Ceizyk, Siyoung Jang, Anand Desai, Dave Abraham, Lars Ewell, Christopher Watchman, Russ Hamilton, Beng-Hoey Jo, Ulf Karlsson, Lexie Smith-Raymond
• Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (Strahlenther Onkol) Vol. 187 Issue 9 Pg. 568-74 (Sep 2011) ISSN: 1439-099X [Electronic] Germany
• PMID: 21713392 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Prednisone

Topics

• Adult
• Anti-Inflammatory Agents (administration & dosage)
• Drug Resistance
• Feasibility Studies
• Female
• Follow-Up Studies
• Graves Ophthalmopathy (radiotherapy)
• Humans
• Middle Aged
• Prednisone (administration & dosage)
• Radiotherapy Dosage
• Radiotherapy Planning, Computer-Assisted
• Radiotherapy, Intensity-Modulated (instrumentation)
• Retrospective Studies
• Tomography, Spiral Computed (instrumentation)
• Young Adult