Abstract | OBJECTIVE: MATERIALS AND METHODS: Male Sprague Dawley rats were fed high-fat diet (HFD) for the first eight weeks, to develop obesity-induced dyslipidemia. Later on piperine (40 mg / kg) and sibutramine (5 mg / kg) were administered for three weeks along with the continuation of HFD to two separate groups, which served as the test and standard groups, respectively. Body weight, food intake, serum triglyceride, total cholesterol, LDL, VLDL, and HDL were measured at the end of the fourth, eighth (before treatment), and eleventh ( after treatment) week, while the fat mass was measured at the end of the eleventh week in the normal, HFD-control, test, and standard groups. RESULTS: CONCLUSION: The above results suggest that piperine possesses potential fat reducing and lipid lowering effects, without any change in food appetite, at a small dose of 40 mg / kg. The mechanism of action for such an activity needs to be determined. However, looking to structural similarity with the presently known Melanocortin-4 (MC-4) agonists, involvement of MC-4 receptors in its activity can be guessed.
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Authors | Shreya S Shah, Gaurang B Shah, Satbeer D Singh, Priyanshi V Gohil, Kajal Chauhan, Khyati A Shah, Mehul Chorawala |
Journal | Indian journal of pharmacology
(Indian J Pharmacol)
Vol. 43
Issue 3
Pg. 296-9
(May 2011)
ISSN: 1998-3751 [Electronic] India |
PMID | 21713094
(Publication Type: Journal Article)
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