Metabolites and tissue distribution of resveratrol in the pig.

Abstract

SCOPE:

trans-Resveratrol (RES) and/(or) its metabolites exert many effects in vivo. Our aim was to study the metabolism and tissue distribution of RES using the pig, a mammal physiologically close to humans.

METHODS AND RESULTS:

Forty-seven tissues, organs and fluids were analyzed 6 h after intragastric RES administration (5.9 mg/kg body weight) using HPLC-MS/MS. Twelve RES and seven dihydroresveratrol (DH-RES) metabolites were detected. DH-RES was the main metabolite in cecum, colon and rectum, whereas RES-3-O-glucuronide was the most abundant one in fluids and organs. Approximately 74.5% of the total RES administered was recovered in the form of RES, DH-RES and derived metabolites (65.1% along the gastrointestinal tract, 7.7% in urine, 1.2% in bile and 0.5% in organs). We report here, for the first time, the occurrence of RES ribosyl-sulfate derivative, DH-RES diglucuronide, DH-RES sulfoglucuronide and DH-RES disulfate as well as the metabolic profile of RES and DH-RES in the aorta, lymph, lymph node, ovaries, uterus, cerebellum, pancreas, urinary bladder tissue, fat and muscle.

CONCLUSION:

This study contributes to the clarification of the metabolism and tissue distribution of RES and could help to further understand the mechanisms underlying its effects.

• Authors: María Azorín-Ortuño, María J Yáñez-Gascón, Fernando Vallejo, Francisco J Pallarés, Mar Larrosa, Ricardo Lucas, Juan C Morales, Francisco A Tomás-Barberán, María T García-Conesa, Juan C Espín
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 55 Issue 8 Pg. 1154-68 (Aug 2011) ISSN: 1613-4133 [Electronic] Germany
• PMID: 21710561 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Stilbenes
• Resveratrol

Topics

• Animals
• Gastrointestinal Tract (metabolism)
• Resveratrol
• Stilbenes (metabolism)
• Swine
• Tissue Distribution