Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.

Abstract

PURPOSE:

Although a number of genetic studies have attempted to link organic cation transporter 1/2 (OCTN1/2) polymorphisms to susceptibility of Crohn's disease (CD), the results were often inconsistent. The present study aimed at investigating the associations.

METHODS:

The PubMed, EBSCO, and BIOSIS databases were searched to identify eligible studies which were published in English before April 2011. The association was assessed by odds ratio (OR) with 95% confidence intervals (CI).

RESULTS:

A total of 15 case-control studies, containing 4,489 cases/5,351 controls for OCTN1 and 4,474 cases/5,377 controls for OCTN2 were included. Overall, significant associations were found between OCTN1/2 polymorphisms and susceptibility of Crohn's disease for all genetic models. In the subgroup analyses, significant associations were found in the Caucasian population for OCTN1 (TT vs. CC: OR = 1.425, 95% CI 1.247-1.628; TT vs. CT: OR = 1.299, 95% CI 1.149-1.468; dominant model: OR = 1.344, 95% CI 1.197-1.508; and recessive model: OR = 1.179, 95% CI 1.066-1.305) and for OCTN2 (CC vs. GG: OR = 1.309, 95% CI 1.078-1.588; CC vs. CG: OR = 1.200, 95% CI 1.002-1.438; dominant model (OR = 1.231, 95% CI 1.036-1.462; recessive model: OR = 1.148, 95% CI 1.031-1.279). Significant associations were not found in the East Asian population.

CONCLUSIONS:

This meta-analysis suggests that OCTN1/2 polymorphisms were associated with susceptibility of CD in the Caucasian population but not in the East Asian population.

• Authors: Chao Xuan, Bei-Bei Zhang, Tao Yang, Kai-Feng Deng, Ming Li, Rui-Juan Tian
• Journal: International journal of colorectal disease (Int J Colorectal Dis) Vol. 27 Issue 1 Pg. 11-9 (Jan 2012) ISSN: 1432-1262 [Electronic] Germany
• PMID: 21706137 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Organic Cation Transport Proteins
• SLC22A4 protein, human
• SLC22A5 protein, human
• Solute Carrier Family 22 Member 5
• Symporters

Topics

• Confidence Intervals
• Crohn Disease (genetics)
• Gene Frequency (genetics)
• Genetic Association Studies
• Genetic Predisposition to Disease
• Humans
• Odds Ratio
• Organic Cation Transport Proteins (genetics)
• Polymorphism, Single Nucleotide (genetics)
• Solute Carrier Family 22 Member 5
• Symporters