In vivo cancer imaging by poly(ethylene glycol)-b-poly(ɛ-caprolactone) micelles containing a near-infrared probe.

Abstract

Noninvasive near-infrared (NIR) fluorescence imaging is a promising technique for the intraoperative assessment of solid tumor removal. We incorporated a lipophilic NIR probe, 1,1'-dioctadecyltetramethyl indotricarbocyanine iodide (DiR), in poly(ethylene glycol)-b-poly(ɛ-caprolactone) (PEG-b-PCL) micelles, resulting in DiR solubilization in water, occupying nanoscopic PEG-b-PCL micelles. DiR in a self-quenched or nonquenched state showed different kinetics of release from PEG-b-PCL micelles in vitro; however, both obtained high tumor delineation (tumor-to-muscle ratio of 30-43 from collected organs). These results suggest that PEG-b-PCL micelles with DiR are a promising nanosized imaging agent that will provide a basis for enhanced surgical guidance via NIR visualization of tumors.

FROM THE CLINICAL EDITOR:

In this paper, noninvasive near-infrared fluorescence imaging coupled with specific lipophilic probes is discussed as a promising technique for intraoperative assessment of solid tumor removal, leading to optimized outcomes for in toto removal of tumors.

• Authors: Hyunah Cho, Guilherme L Indig, Jamey Weichert, Ho-Chul Shin, Glen S Kwon
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 8 Issue 2 Pg. 228-36 (Feb 2012) ISSN: 1549-9642 [Electronic] United States
• PMID: 21704593 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Carbocyanines
• Fluorescent Dyes
• Micelles
• Polyesters
• Water
• polycaprolactone
• Polyethylene Glycols
• 3,3'-dioctadecylindocarbocyanine

Topics

• Carbocyanines (chemistry)
• Diagnostic Imaging (methods)
• Fluorescent Dyes (chemistry)
• Humans
• Micelles
• Neoplasms (diagnosis)
• Particle Size
• Polyesters (chemistry)
• Polyethylene Glycols (chemistry)
• Solubility
• Water