Gold-doxorubicin nanoconjugates for overcoming multidrug resistance.

Abstract

Multidrug resistance (MDR) is a major clinical obstacle to the success of cancer chemotherapy. Here we developed a gold-doxorubicin (DOX) nanoconjugates system to overcome MDR. Gold nanoparticles (AuNPs) were first PEGylated as Au-PEG-NH(2), and DOX was then grafted onto AuNPs via a cleavable disulfide linkage (Au-PEG-SS-DOX). Confocal images revealed that the extent of intracellular uptake of Au-PEG-SS-DOX was greater than that of free DOX in the MDR cells, and inductively coupled plasma mass spectroscopy analysis further confirmed that AuNPs significantly increased the level of drug accumulation in MDR cells at a nanoparticles dose greater than 15 μM. The cytotoxicity study demonstrated that the Au-PEG-SS-DOX nanoconjugates system efficiently released the anticancer drug DOX and enhanced its cytotoxicity against MDR cancer cells. This study highlights the potential of using AuNPs for overcoming of MDR in cancer chemotherapy.

FROM THE CLINICAL EDITOR:

This study demonstrates that gold nanoparticles can be successfully applied to overcome MDR in cancer chemotherapy.

• Authors: Yan-Juan Gu, Jinping Cheng, Cornelia Wing-Yin Man, Wing-Tak Wong, Shuk Han Cheng
• Journal: Nanomedicine : nanotechnology, biology, and medicine (Nanomedicine) Vol. 8 Issue 2 Pg. 204-11 (Feb 2012) ISSN: 1549-9642 [Electronic] United States
• PMID: 21704592 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Drug Carriers
• Polyethylene Glycols
• Gold
• Doxorubicin

Topics

• Doxorubicin (chemistry, pharmacology)
• Drug Carriers (adverse effects, chemistry)
• Drug Resistance, Multiple (drug effects)
• Gold (adverse effects, chemistry)
• Hep G2 Cells
• Humans
• Metal Nanoparticles (adverse effects, chemistry)
• Microscopy, Confocal
• Molecular Structure
• Polyethylene Glycols (chemistry)