Anti-ulcerogenic and proton pump (H+, K+ ATPase) inhibitory activity of Kolaviron from Garcinia kola Heckel in rodents.

Abstract

Anti-ulcer potential and proton pump inhibitory activity of kolaviron (KV) isolated from Garcinia kola Heckel has been evaluated using different ulcer models. Cold-restraint (CRU), aspirin (ASP), alcohol (AL), pyloric ligation (PL) induced gastric ulcer models were used to assess anti-ulcerogenic activity of KV in rats. Effects of KV on gastric juice for free and total acidity, peptic activity and mucin secretion were also evaluated. The H+, K+-ATPase activity was assayed in gastric microsomes, spectrophotometrically. Results of this study showed that KV (200 mg/kg) reduced the incidence of ulcers in CRU (69.0%), PL (67.6%), ASP (68.6%) and AL (51.5%). Reductions were also observed in free acidity (32.6%), total acidity (56.2%) and peptic activity (35.4%) with increase in mucin secretion by 40.1%. KV inhibited the H+,K+-ATPase activity with IC50 of 43.8 microg/ml compared with omeprazole with IC50 of 32.3 microg/ml. KV showed both cytoprotective and anti-secretory potentials against peptic ulcer models, and a proton pump inhibitory activity. KV may emerge as a potent anti-ulcer compound.

• Authors: Samuel A Onasanwo, Neetu Singh, Samuel B Olaleye, Gautam Palit
• Journal: Indian journal of experimental biology (Indian J Exp Biol) Vol. 49 Issue 6 Pg. 461-8 (Jun 2011) ISSN: 0019-5189 [Print] India
• PMID: 21702226 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Ulcer Agents
• Flavonoids
• Plant Extracts
• Proton Pump Inhibitors
• kolaviron

Topics

• Animals
• Anti-Ulcer Agents (isolation & purification, pharmacology)
• Flavonoids (isolation & purification, pharmacology)
• Garcinia kola (chemistry)
• Gastric Juice (drug effects, metabolism)
• Plant Extracts (pharmacology)
• Plants, Medicinal
• Proton Pump Inhibitors
• Rats
• Rats, Sprague-Dawley
• Stomach Ulcer (etiology, prevention & control)