Early-onset postirradiation sarcoma of the tongue after pseudotumor phase.

Abstract

Radiation-induced sarcoma usually develops after an interval of more than 10 years from the completion of radiation therapy to the diagnosis of secondary sarcoma. However, the theory of radiation-induced transformation does not rule out postirradiation sarcomas with a short latency period. We experienced the case of a patient with postirradiation leiomyosarcoma of the tongue, which occurred 19 months after he had received chemoradiotherapy. Besides the short latency period, a pseudotumor stage developed between the time of radiation exposure and the development of leiomyosarcoma. In this article, we also describe an immunohistochemical approach to diagnose leiomyosarcoma and the efficacy of a gemcitabine and docetaxel regimen.

• Authors: Takushi Miyoshi, Shinji Takebayashi, Chiaki Suzuki, Nao Hiwatashi, Hiroki Ikeda, Kazuo Ono, Makoto Miura
• Journal: ORL; journal for oto-rhino-laryngology and its related specialties (ORL J Otorhinolaryngol Relat Spec) Vol. 73 Issue 4 Pg. 201-5 ( 2011) ISSN: 1423-0275 [Electronic] Switzerland
• PMID: 21701246 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright © 2011 S. Karger AG, Basel.

Topics

• Biopsy
• Diagnosis, Differential
• Granuloma, Plasma Cell (pathology, radiotherapy)
• Humans
• Male
• Middle Aged
• Neoplasms, Radiation-Induced (diagnosis, etiology)
• Sarcoma (diagnosis, etiology)
• Time Factors
• Tongue Diseases (pathology, radiotherapy)
• Tongue Neoplasms (diagnosis, etiology)