Abstract | BACKGROUND AND PURPOSE: METHODS: Patients undergoing carotid endarterectomy were randomized double-blind to ARC1779 or placebo administered intravenously. Transcranial Doppler recording, to detect cerebral embolic signals, was performed in the first 3 hours postoperatively. The primary end point was time to first embolic signals. RESULTS: Thirty-six patients were recruited, 18 in each arm. The Kaplan-Meier median time to first embolic signals was 83.6 minutes for ARC1779 compared with 5.5 minutes for placebo. Using Cox proportional hazards embolic signals occurred statistically significantly later on ARC1779 (P=0.007). Reduced embolic signals counts were correlated with inhibition of von Willebrand factor activity (P=0.03). Increased perioperative bleeding and anemia were seen with ARC1779. CONCLUSIONS:
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Authors | Hugh S Markus, Charles McCollum, Chris Imray, Michael A Goulder, Jim Gilbert, Alice King |
Journal | Stroke
(Stroke)
Vol. 42
Issue 8
Pg. 2149-53
(Aug 2011)
ISSN: 1524-4628 [Electronic] United States |
PMID | 21700934
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- ARC 1779
- Aptamers, Nucleotide
- von Willebrand Factor
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Aptamers, Nucleotide
(therapeutic use)
- Carotid Stenosis
(surgery)
- Double-Blind Method
- Endarterectomy, Carotid
(adverse effects)
- Female
- Follow-Up Studies
- Humans
- Intention to Treat Analysis
- Intracranial Embolism
(etiology, prevention & control)
- Male
- Middle Aged
- Platelet Aggregation
(drug effects)
- Treatment Outcome
- von Willebrand Factor
(antagonists & inhibitors)
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