[Invasive candidiasis in liver transplant recipient: early rescue antifungal treatment].

Abstract

BACKGROUND:

Some liver transplant recipients could be at risk for candidemia or invasive candidiasis during the immediate postoperative period after transplantation. Prophylaxis is the best strategy to reduce the incidence of invasive fungal infection caused by Candida species in high-risk liver transplant recipients (HR-LTR), but in cases of suspected breakthrough invasive fungal infection due to Candida, both a rapid diagnosis process and early antifungal treatment are the most important factors impacting on the prognosis.

CLINICAL CASE:

We report a case of early rescue treatment with anidulafungin in a HR-LTR with complicated postoperative course. We discuss risk factors, prophylaxis, sensitivity of biomarkers, and characteristics of antifungal management.

CONCLUSIONS:

Early rescue antifungal treatment using candins improves the prognosis in HR-LTR suffering from invasive candidiasis.

• Authors: Juan Carlos Pozo-Laderas, Antonio Pontes-Moreno
• Journal: Revista iberoamericana de micologia (Rev Iberoam Micol) 2011 Jul-Sep Vol. 28 Issue 3 Pg. 124-8 ISSN: 2173-9188 [Electronic] Spain
• Vernacular Title: Candidiasis invasora en un receptor de trasplante hepático: tratamiento antifúngico de rescate precoz.
• PMID: 21700232 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2011 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

Chemical References

• Antifungal Agents
• Echinocandins
• Anidulafungin

Topics

• Acute Kidney Injury (complications, therapy)
• Adult
• Anidulafungin
• Antifungal Agents (administration & dosage, therapeutic use)
• Bacteremia (etiology)
• Blood Loss, Surgical
• Candidemia (diagnosis, drug therapy, etiology)
• Cross Infection (diagnosis, drug therapy, etiology, microbiology)
• Early Diagnosis
• Echinocandins (administration & dosage, therapeutic use)
• Hepatitis C, Chronic (complications, surgery)
• Humans
• Immunocompromised Host
• Liver Cirrhosis, Alcoholic (complications, surgery)
• Liver Transplantation
• Male
• Methicillin-Resistant Staphylococcus aureus (isolation & purification)
• Opportunistic Infections (diagnosis, drug therapy, etiology, microbiology)
• Postoperative Complications (diagnosis, drug therapy, etiology, microbiology)
• Renal Dialysis
• Reoperation
• Risk
• Staphylococcal Infections (etiology)