Abstract | BACKGROUND & AIMS: Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable molecules secreted by the mammalian gastrointestinal tract. Foveolar hyperplasia, spasmolytic polypeptide (TFF2)-expressing metaplasia, and intestinal metaplasia are histologic changes observed in patients with atrophic gastritis; they express TFF1, TFF2, and TFF3, respectively. We investigated whether serum levels of TFF can be used as markers for gastric cancer screening. METHODS: RESULTS: Using a cutoff of 3.6 ng/mL, the level of TFF3 was significantly increased in serum samples from patients with cancer (odds ratio, 18.1; 95% confidence interval, 11.2-29.2); using this test, patients with cancer were identified with 80.9% sensitivity and 81.0% specificity. The test for TFF3 had a significantly higher odds ratio than that for pepsinogen. A test for the combination of TFF3 and pepsinogen had better results than the test for only pepsinogen. CONCLUSIONS:
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Authors | Susumu Aikou, Yasukazu Ohmoto, Toshiaki Gunji, Nobuyuki Matsuhashi, Hiroshi Ohtsu, Hirona Miura, Kensuke Kubota, Yukinori Yamagata, Yasuyuki Seto, Atsushi Nakajima, James R Goldenring, Michio Kaminishi, Sachiyo Nomura |
Journal | Gastroenterology
(Gastroenterology)
Vol. 141
Issue 3
Pg. 837-845.e1-7
(Sep 2011)
ISSN: 1528-0012 [Electronic] United States |
PMID | 21699780
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
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Copyright | Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers, Tumor
- Peptides
- TFF1 protein, human
- TFF2 protein, human
- TFF3 protein, human
- Trefoil Factor-1
- Trefoil Factor-2
- Trefoil Factor-3
- Tumor Suppressor Proteins
- Pepsinogen A
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Topics |
- Adult
- Aged
- Biomarkers, Tumor
(blood)
- Case-Control Studies
- Early Detection of Cancer
(methods)
- Helicobacter Infections
(blood)
- Helicobacter pylori
- Humans
- Japan
- Male
- Middle Aged
- Pepsinogen A
(blood)
- Peptides
(blood)
- Sensitivity and Specificity
- Stomach Neoplasms
(blood, diagnosis)
- Trefoil Factor-1
- Trefoil Factor-2
- Trefoil Factor-3
- Tumor Suppressor Proteins
(blood)
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