Abstract | BACKGROUND: OBJECTIVE: DESIGN: A community-based prospective study was conducted in 2890 men and women aged ≥65 y, who were free of known CHD at baseline and who were followed from 1992 to 2006. Cardiovascular disease risk factors and plasma phospholipid fatty acids were measured at baseline by using standardized methods. Incident CHD was ascertained prospectively and was centrally adjudicated by using medical records. Risk was assessed by using multivariable-adjusted Cox proportional hazards. RESULTS: During 29,835 person-years of follow-up, 631 CHD and 71 SCA events occurred. Both 18:1n-7 and 16:1n-9 were associated with a higher risk of SCA [multivariable-adjusted hazard ratio (95% CI) for the interquintile range: 7.63 (2.58, 22.6) for 18:1n-7 and 2.30 (1.16, 4.55) for 16:1n-9] but not of total CHD, fatal CHD, or NFMI. In secondary analyses censored to mid-follow-up (7 y) to minimize the effects of changes in concentrations over time, 16:1n-9 was also associated with a significantly higher risk of total CHD (2.11; 1.76, 2.54), including a higher risk of CHD death, NFMI, and SCA; 16:0 and 16:1n-7 were not associated with clinical CHD outcomes. CONCLUSION: Higher plasma phospholipid 18:1n-7 and 16:1n-9 concentrations were prospectively associated with an elevated risk of SCA but not of other CHD events, except in secondary analyses.
|
Authors | Jason H Y Wu, Rozenn N Lemaitre, Fumiaki Imamura, Irena B King, Xiaoling Song, Donna Spiegelman, David S Siscovick, Dariush Mozaffarian |
Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 94
Issue 2
Pg. 431-8
(Aug 2011)
ISSN: 1938-3207 [Electronic] United States |
PMID | 21697077
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Fatty Acids
- Phospholipids
|
Topics |
- Aged
- Aged, 80 and over
- Cohort Studies
- Coronary Disease
(etiology)
- Death, Sudden, Cardiac
(etiology)
- Diet
- Fatty Acids
(metabolism)
- Female
- Humans
- Lipogenesis
- Male
- Phospholipids
(blood)
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
|