Intra-arterial nimodipine infusion for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.

Abstract

This study evaluated the efficacy of intra-arterial nimodipine infusion for symptomatic vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH). Clinical data collected from 42 consecutive patients with symptomatic vasospasm after aSAH were retrospectively reviewed. Forty-two patients underwent 101 sessions of intra-arterial nimodipine infusion. Angiographic response, immediate clinical response, and clinical outcome were evaluated at discharge and six months later. Angiographic improvement was achieved in 82.2% of patients. The immediate clinical improvement rate was 68.3%, while the deterioration rate was 5.0%. A favorable clinical outcome was achieved in 76.2% at discharge and 84.6% six months. Vasospasm-related infarction occurred in 21.4%. There was no drug-related complication. The nimodipine group showed satisfactory outcomes. Nimodipine can be recommended as an effective and safe intra-arterial agent for the treatment of symptomatic vasospasm after aSAH.

• Authors: W-S Cho, H-S Kang, J E Kim, O-K Kwon, C W Oh, Y J Son, B J Know, C Jung, M H Hang
• Journal: Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences (Interv Neuroradiol) Vol. 17 Issue 2 Pg. 169-78 (Jun 2011) ISSN: 1591-0199 [Print] United States
• PMID: 21696654 (Publication Type: Journal Article)

Chemical References

• Calcium Channel Blockers
• Nimodipine

Topics

• Adult
• Calcium Channel Blockers (administration & dosage, adverse effects)
• Cerebral Angiography
• Female
• Follow-Up Studies
• Humans
• Infusions, Intra-Arterial
• Male
• Middle Aged
• Nimodipine (administration & dosage, adverse effects)
• Retrospective Studies
• Subarachnoid Hemorrhage (complications, diagnostic imaging, drug therapy)
• Treatment Outcome
• Vasospasm, Intracranial (diagnostic imaging, drug therapy, etiology)