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Local giant cell foreign body reaction after silicone injection for fecal incontinence in humans: two case reports.

Abstract
Since the 1990s, one of the methods used for treating fecal incontinence due to internal anal sphincter defects has been the injection of bulking agents. The aim of this paper is to report two cases of local giant cell foreign body reaction after injection of PTQ(TM) in humans. To the best of the authors' knowledge, this is the first report of an adverse immune response to silicone injection in humans.
AuthorsB van Wunnik, A Driessen, C Baeten
JournalTechniques in coloproctology (Tech Coloproctol) Vol. 16 Issue 5 Pg. 395-7 (Oct 2012) ISSN: 1128-045X [Electronic] Italy
PMID21695441 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Biocompatible Materials
  • Silicones
Topics
  • Biocompatible Materials (adverse effects, therapeutic use)
  • Fecal Incontinence (drug therapy)
  • Foreign-Body Reaction (chemically induced, immunology, pathology)
  • Giant Cells, Foreign-Body (pathology)
  • Humans
  • Male
  • Middle Aged
  • Silicones (adverse effects, therapeutic use)

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