Oral choline supplementation in children with intestinal failure.

Abstract

Choline deficiency leads to steatohepatitis, elevated transaminases, susceptibility to septic shock, and an increased risk of central catheter thrombosis. Children with intestinal failure (IF) are at risk for choline deficiency. In an unblinded, open-label study, we studied 7 children with IF on parenteral nutrition, measured their plasma free choline level, and, if low, supplemented enterally with adequate intake (AI) doses of choline. Four to 6 weeks later we remeasured their plasma free choline. Unlike adults, infants did not respond to oral choline supplementation at AI doses. Additionally, we have calculated plasma free choline percentiles versus age for normal children.

• Authors: Anthony L Guerrerio, Lynn Mattis, Kim G Conner, Jenifer Hampsey, D Mikis Stasinopoulos, Robert DeJong, Emad M Boctor, Shelia Sheth, Ulrike M Hamper, Ann O Scheimann
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 53 Issue 1 Pg. 115-9 (Jul 2011) ISSN: 1536-4801 [Electronic] United States
• PMID: 21694550 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Choline

Topics

• Administration, Oral
• Adolescent
• Age Factors
• Child
• Choline (blood, therapeutic use)
• Choline Deficiency (etiology, prevention & control)
• Dietary Supplements
• Female
• Humans
• Infant
• Intestinal Diseases (blood, diet therapy, physiopathology)
• Intestines (physiopathology)
• Male
• Parenteral Nutrition
• Pilot Projects
• Short Bowel Syndrome (blood, diet therapy, physiopathology)