Studies on the anti-tumor-promoting activity of naturally occurring substances. IV. Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, inhibits the promotion of skin tumor formation by 12-O-tetradecanoylphorbol-13-acetate in 7,12-dimethylbenz[a]anthracene-initiated mice.

Abstract

Since Pd-II [(+)anomalin, (+)praeruptorin B], a seselin-type coumarin, was found to inhibit tumor promoter induced phenomenon in vitro, the effect of Pd-II on the in vivo tumor-promoting action of 12-O-tetradecanoylphorbol-13-acetate (TPA) in 7,12-dimethylbenz[a]anthracene-initiated mouse skin was investigated. Pd-II, applied 40 min before the TPA treatment, at a dose of 10 mumol/painting, completely suppressed tumor formation up to 20 weeks of tumor promotion, without any toxicity. Besides Pd-II, various anti-tumor-promoter coumarins were found in the traditional Chinese medicine Qian-Hu, from which Pd-II was obtained. These coumarins may be useful for the development of an effective method to prevent cancer.

• Authors: H Nishino, T Okuyama, M Takata, S Shibata, H Tokuda, J Takayasu, T Hasegawa, A Nishino, H Ueyama, A Iwashima
• Journal: Carcinogenesis (Carcinogenesis) Vol. 11 Issue 9 Pg. 1557-61 (Sep 1990) ISSN: 0143-3334 [Print] England
• PMID: 2169356 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents
• Coumarins
• Drugs, Chinese Herbal
• Phosphates
• Phospholipids
• 9,10-Dimethyl-1,2-benzanthracene
• anomalin
• Tetradecanoylphorbol Acetate

Topics

• 9,10-Dimethyl-1,2-benzanthracene
• Animals
• Antineoplastic Agents
• Cell Line
• Coumarins (pharmacology, therapeutic use)
• Drugs, Chinese Herbal (therapeutic use)
• Female
• HeLa Cells (drug effects, metabolism)
• Herpesvirus 4, Human (drug effects, growth & development)
• Humans
• Mice
• Mice, Inbred ICR
• Phosphates (metabolism)
• Phospholipids (metabolism)
• Skin Neoplasms (chemically induced, prevention & control)
• Tetradecanoylphorbol Acetate (toxicity)
• Virus Activation (drug effects)