Abstract | BACKGROUND: OBJECTIVES: This study was designed to compare the safety and efficacy of PDT using ICG and PDT using IAA in the treatment of mild to moderate acne vulgaris. METHODS: In this prospective, single-blind, clinical trial, 34 patients with mild to moderate acne were treated with IAA with green light (520 nm) on half of the face and with ICG with near-infrared radiation (805 nm) on the other half. The procedure was carried out five times at 1-week intervals. RESULTS: With regard to acne lesions (inflammatory and noninflammatory) and sebum secretion, there were statistically significant reductions at each time point compared with the baseline values (P < 0·05). However, there were no statistically significant differences between the two treatment types (P > 0·05). Both ICG- PDT and IAA- PDT showed better responses for inflammatory lesions than for noninflammatory lesions (P < 0·05). Subjective satisfaction score were statistically significant at 4 and 5 weeks of treatment as well as at 1, 2 and 3 months follow-up (P < 0·05). CONCLUSIONS: Both PDT with ICG and PDT with IAA are safe and effective for the treatment of mild to moderate acne vulgaris.
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Authors | M S Jang, K S Doh, J S Kang, Y S Jeon, K S Suh, S T Kim |
Journal | The British journal of dermatology
(Br J Dermatol)
Vol. 165
Issue 5
Pg. 1095-100
(Nov 2011)
ISSN: 1365-2133 [Electronic] England |
PMID | 21692772
(Publication Type: Clinical Trial, Comparative Study, Journal Article)
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Copyright | © 2011 The Authors. BJD © 2011 British Association of Dermatologists. |
Chemical References |
- Dermatologic Agents
- Indoleacetic Acids
- Ointments
- Photosensitizing Agents
- indoleacetic acid
- Indocyanine Green
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Topics |
- Acne Vulgaris
(drug therapy, metabolism)
- Administration, Cutaneous
- Adolescent
- Adult
- Dermatologic Agents
(administration & dosage, adverse effects)
- Drug Therapy, Combination
- Female
- Humans
- Indocyanine Green
(administration & dosage, adverse effects)
- Indoleacetic Acids
(administration & dosage, adverse effects)
- Male
- Ointments
- Patient Satisfaction
- Photochemotherapy
(methods)
- Photosensitizing Agents
(administration & dosage, adverse effects)
- Sebum
(metabolism)
- Single-Blind Method
- Treatment Outcome
- Young Adult
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