Abstract |
Therapeutic options for patients with metastatic castration-resistant prostate cancer are increasing, spurring an urgent need to better understand which treatments are best for individual patients. The recent approval of a first-in-class agent, sipuleucel-T, has intensified this need. This therapeutic cancer vaccine has demonstrated a survival advantage in two Phase III trials, but does not alter progression in the short term. Therefore, a new therapeutic approach for patients with metastatic castration-resistant prostate cancer is taking shape, based on broader understanding of available therapies. This new clinical approach seeks to maximize patient benefit from treatment, minimize associated toxicities, and may have far-reaching implications for other therapeutic cancer vaccines currently in clinical development.
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Authors | Ravi A Madan, Jeanny B Aragon-Ching, James L Gulley, William L Dahut |
Journal | Expert review of vaccines
(Expert Rev Vaccines)
Vol. 10
Issue 6
Pg. 743-53
(Jun 2011)
ISSN: 1744-8395 [Electronic] England |
PMID | 21692697
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Review)
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Chemical References |
- Cancer Vaccines
- Tissue Extracts
- sipuleucel-T
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Topics |
- Cancer Vaccines
(administration & dosage, immunology)
- Clinical Trials, Phase III as Topic
- Humans
- Male
- Neoplasm Metastasis
(immunology, therapy)
- Prostatic Neoplasms
(immunology, secondary, therapy)
- Survival Analysis
- Tissue Extracts
(administration & dosage, immunology)
- Treatment Outcome
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