Lymph node yield following injection of patent blue V dye into colorectal cancer specimens.

Abstract

AIM:

The study aimed to assess whether the ex vivo injection of patent blue V dye would increase lymph node yield in operative specimens of colorectal cancer.

METHOD:

A randomized controlled trial was carried out in which patients undergoing resection for colonic cancer were allocated to patent V blue or no patent blue V dye submucosal injection of the operative specimen. The number of lymph nodes found in each group was compared.

RESULTS:

Between 1 January and 31 December 2008, 68 patients were randomized. Thirty-three patients received patent blue V dye and 34 did not. In the former group the median number of blue nodes identified was 11, compared with a median of 9 in the no dye group. After the application of Carnoy's solution lymph node count was 16 in each group. There was no significant difference between all these results.

CONCLUSION:

Ex vivo injection of patent blue V dye submucosally in a peritumour location did not increase the lymph node count or the percentage of specimens having more than 12 lymph nodes identified.

• Authors: C Wakeman, V Yu, R Chandra, M Staples, R Wale, C McLean, S Bell
• Journal: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (Colorectal Dis) Vol. 13 Issue 9 Pg. e266-9 (Sep 2011) ISSN: 1463-1318 [Electronic] England
• PMID: 21689343 (Publication Type: Journal Article, Randomized Controlled Trial)
• Copyright: © 2011 The Authors. Colorectal Disease © 2011 The Association of Coloproctology of Great Britain and Ireland.

Chemical References

• Carnoy's solution
• Coloring Agents
• Fixatives
• Rosaniline Dyes
• Ethanol
• Chloroform
• sulfan blue
• Acetic Acid

Topics

• Acetic Acid
• Adenocarcinoma (pathology, secondary)
• Aged
• Chloroform
• Colorectal Neoplasms (pathology, surgery)
• Coloring Agents
• Ethanol
• Female
• Fixatives
• Humans
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Male
• Neoplasm Staging
• Rosaniline Dyes
• Sentinel Lymph Node Biopsy