HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

[Disordered phosphorus metabolism and its correction in the acute period of severe craniocerebral trauma].

Abstract
Marked hypophosphatemia was discovered in 78 patients in the acute period of severe craniocerebral injury. It led to a decrease of the level of 2,3-diphosphoglycerate (2,3 DPG) and ATP in the red cells. The reduced ATP level in the red cells was one of the causes of reduced Ca2+ ATPase activity in their membranes. Intravenous infusion of 6.8% potassium dihydrophosphate solution prevented the development of hypophosphatemia and reduction of the content of 2,3 DPG and ATP in the red cells and Ca2+ ATPase activity in their membranes, which facilitated improvement in the course of acute posttraumatic period in patients with severe craniocerebral injury and decrease of mortality.
AuthorsS A Pas'ko, T G Volosheniuk
JournalZhurnal voprosy neirokhirurgii imeni N. N. Burdenko (Zh Vopr Neirokhir Im N N Burdenko) 1990 May-Jun Issue 3 Pg. 14-6 ISSN: 0042-8817 [Print] Russia (Federation)
Vernacular TitleNarushenie fosfornogo obmena i ego korrektsiia v ostrom periode tiazheloĭ cherepno-mozgovoĭ travmy.
PMID2168644 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Diphosphoglyceric Acids
  • Phosphates
  • Potassium Compounds
  • 2,3-Diphosphoglycerate
  • Adenosine Triphosphate
  • potassium phosphate
  • Calcium-Transporting ATPases
  • Potassium
Topics
  • 2,3-Diphosphoglycerate
  • Acute Disease
  • Adenosine Triphosphate (blood)
  • Brain Injuries (blood, complications, therapy)
  • Calcium-Transporting ATPases (blood)
  • Combined Modality Therapy
  • Critical Care
  • Diphosphoglyceric Acids (blood)
  • Humans
  • Phosphates (administration & dosage, blood)
  • Phosphorus Metabolism Disorders (blood, etiology, therapy)
  • Potassium (administration & dosage, blood)
  • Potassium Compounds

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: